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	<title>Comments on: Mitochondria, autism and thimerosal</title>
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	<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/</link>
	<description>Autism news and opinion</description>
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		<title>By: Left Brain/Right Brain &#187; Blog Archive &#187; Mitochondra and vaccines - the science</title>
		<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/#comment-49280</link>
		<dc:creator>Left Brain/Right Brain &#187; Blog Archive &#187; Mitochondra and vaccines - the science</dc:creator>
		<pubDate>Sat, 26 Apr 2008 08:29:21 +0000</pubDate>
		<guid isPermaLink="false">http://leftbrainrightbrain.co.uk/?p=777#comment-49280</guid>
		<description>[...] my regular readers will note I have &#8211; with some frustration &#8211; been blogging the responses of some Mitochondrial heavy hitters in recent [...]</description>
		<content:encoded><![CDATA[<p>[...] my regular readers will note I have &#8211; with some frustration &#8211; been blogging the responses of some Mitochondrial heavy hitters in recent [...]</p>
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		<title>By: Schwartz</title>
		<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/#comment-49155</link>
		<dc:creator>Schwartz</dc:creator>
		<pubDate>Thu, 24 Apr 2008 05:49:32 +0000</pubDate>
		<guid isPermaLink="false">http://leftbrainrightbrain.co.uk/?p=777#comment-49155</guid>
		<description>Joseph,

You have done a great deal to discredit the validity of the prevalence trends (and convinced me to some degree as well).  Why does belief suddenly play into it?  Sure, I might suspect that there has been an increase although less than published, but I know very well, the data is pretty crappy so I don&#039;t really have a strong belief either way on prevalence.  Good data just isn&#039;t available.

If you want to credibly study a possible correlation between a variable and disease or disorder, you need ALL of the following across the WHOLE time period being studied:

1) Credible data of prevalence
2) Credible data of dose
3) Credible data about confounders

I think even you doubt we have #1.  We certainly don&#039;t have #2.  We don&#039;t have #3 either.

If any of these is missing, credible analysis simply can&#039;t be done on correlation.  

I&#039;m not really avoiding anything here.  

This discussion is revolving around the many that claim that trace amounts of mercury are safe in vaccines.  How did they come to that conclusion without knowing what level ethylmercury is toxic to infants?</description>
		<content:encoded><![CDATA[<p>Joseph,</p>
<p>You have done a great deal to discredit the validity of the prevalence trends (and convinced me to some degree as well).  Why does belief suddenly play into it?  Sure, I might suspect that there has been an increase although less than published, but I know very well, the data is pretty crappy so I don&#8217;t really have a strong belief either way on prevalence.  Good data just isn&#8217;t available.</p>
<p>If you want to credibly study a possible correlation between a variable and disease or disorder, you need <span class="caps">ALL</span> of the following across the <span class="caps">WHOLE</span> time period being studied:</p>
<p>1) Credible data of prevalence<br />
2) Credible data of dose<br />
3) Credible data about confounders</p>
<p>I think even you doubt we have #1.  We certainly don&#8217;t have #2.  We don&#8217;t have #3 either.</p>
<p>If any of these is missing, credible analysis simply can&#8217;t be done on correlation.</p>
<p>I&#8217;m not really avoiding anything here.</p>
<p>This discussion is revolving around the many that claim that trace amounts of mercury are safe in vaccines.  How did they come to that conclusion without knowing what level ethylmercury is toxic to infants?</p>
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		<title>By: Joseph</title>
		<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/#comment-49097</link>
		<dc:creator>Joseph</dc:creator>
		<pubDate>Tue, 22 Apr 2008 14:07:27 +0000</pubDate>
		<guid isPermaLink="false">http://leftbrainrightbrain.co.uk/?p=777#comment-49097</guid>
		<description>&lt;i&gt;You still haven’t addressed the problem. If you support using Thimerosal in vaccines, how are you determining what the toxicity level is?&lt;/i&gt;

I haven&#039;t stated that I support thimerosal in vaccines. I don&#039;t have strong feelings that it needs to stay in vaccines. 

But I think it is you who is avoiding the issue, Swartz.

You either believe there has been an autism epidemic or you don&#039;t. If you believe there has been an autism epidemic, that means you believe autism was rare in the 80s, and consequently, you must believe a total exposure of about 70 mcg in infancy is quite safe. It follows that a total exposure of 3 mcg must be extremely safe then.

There are no two ways about it. It doesn&#039;t matter if you believe other things also cause autism. If autism was rare in the 80s, a total exposure of 70 mcg must be quite safe in this context.

It&#039;s also interesting to note that a number of organization have signed &lt;a href=&quot;http://www.autism.org/AutismCollaboration-Articles_of_Membership.pdf&quot; rel=&quot;nofollow&quot;&gt;articles of membership&lt;/a&gt; in a collaboration of sorts. These organizations include the ASA, Generation Rescue, SafeMinds, etc. Among their statements of agreement, they claim that &quot;There is an autism epidemic.&quot; They also  have a claim that seems to indicate that only children are &quot;affected by autism.&quot; That is, autistic adults don&#039;t exist (or they don&#039;t care about autistic adults).
 
Clearly, these organizations are stating, by implication, that a total exposure of 70 mcg of thimerosal in infancy is quite safe when it comes to autism. There&#039;s no way to get out of that one without undermining a key premise of their belief system.</description>
		<content:encoded><![CDATA[<p><i>You still haven&#8217;t addressed the problem. If you support using Thimerosal in vaccines, how are you determining what the toxicity level is?</i></p>
<p>I haven&#8217;t stated that I support thimerosal in vaccines. I don&#8217;t have strong feelings that it needs to stay in vaccines.</p>
<p>But I think it is you who is avoiding the issue, Swartz.</p>
<p>You either believe there has been an autism epidemic or you don&#8217;t. If you believe there has been an autism epidemic, that means you believe autism was rare in the 80s, and consequently, you must believe a total exposure of about 70 mcg in infancy is quite safe. It follows that a total exposure of 3 mcg must be extremely safe then.</p>
<p>There are no two ways about it. It doesn&#8217;t matter if you believe other things also cause autism. If autism was rare in the 80s, a total exposure of 70 mcg must be quite safe in this context.</p>
<p>It&#8217;s also interesting to note that a number of organization have signed <a href="http://www.autism.org/AutismCollaboration-Articles_of_Membership.pdf" rel="nofollow">articles of membership</a> in a collaboration of sorts. These organizations include the <span class="caps">ASA</span>, Generation Rescue, SafeMinds, etc. Among their statements of agreement, they claim that &#8220;There is an autism epidemic.&#8221; They also  have a claim that seems to indicate that only children are &#8220;affected by autism.&#8221; That is, autistic adults don&#8217;t exist (or they don&#8217;t care about autistic adults).</p>
<p>Clearly, these organizations are stating, by implication, that a total exposure of 70 mcg of thimerosal in infancy is quite safe when it comes to autism. There&#8217;s no way to get out of that one without undermining a key premise of their belief system.</p>
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	<item>
		<title>By: Schwartz</title>
		<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/#comment-49087</link>
		<dc:creator>Schwartz</dc:creator>
		<pubDate>Tue, 22 Apr 2008 06:35:00 +0000</pubDate>
		<guid isPermaLink="false">http://leftbrainrightbrain.co.uk/?p=777#comment-49087</guid>
		<description>Joseph,

You still haven&#039;t addressed the problem.  If you support using Thimerosal in vaccines, how are you determining what the toxicity level is?</description>
		<content:encoded><![CDATA[<p>Joseph,</p>
<p>You still haven&#8217;t addressed the problem.  If you support using Thimerosal in vaccines, how are you determining what the toxicity level is?</p>
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		<title>By: Nathan</title>
		<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/#comment-49040</link>
		<dc:creator>Nathan</dc:creator>
		<pubDate>Mon, 21 Apr 2008 01:27:13 +0000</pubDate>
		<guid isPermaLink="false">http://leftbrainrightbrain.co.uk/?p=777#comment-49040</guid>
		<description>Nice advert Liz,
But methylmercury forms a complex with glutathione which is what give methylmercury such a long half-life in the human body (Clarkson 1993) this complex is reabsorbed from the bile.  I don&#039;t think that there is any research that suggests that increased levels of glutathione reduces levels of mercury in the body.  It may work for other metals, I do not know.  Please don&#039;t advertise here.</description>
		<content:encoded><![CDATA[<p>Nice advert Liz,<br />
But methylmercury forms a complex with glutathione which is what give methylmercury such a long half-life in the human body (Clarkson 1993) this complex is reabsorbed from the bile.  I don&#8217;t think that there is any research that suggests that increased levels of glutathione reduces levels of mercury in the body.  It may work for other metals, I do not know.  Please don&#8217;t advertise here.</p>
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		<title>By: Nathan</title>
		<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/#comment-49035</link>
		<dc:creator>Nathan</dc:creator>
		<pubDate>Sun, 20 Apr 2008 23:51:11 +0000</pubDate>
		<guid isPermaLink="false">http://leftbrainrightbrain.co.uk/?p=777#comment-49035</guid>
		<description>By the way both methylmercury and ethylmercury are written as one word (no spaces).</description>
		<content:encoded><![CDATA[<p>By the way both methylmercury and ethylmercury are written as one word (no spaces).</p>
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		<title>By: Nathan</title>
		<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/#comment-49034</link>
		<dc:creator>Nathan</dc:creator>
		<pubDate>Sun, 20 Apr 2008 23:50:02 +0000</pubDate>
		<guid isPermaLink="false">http://leftbrainrightbrain.co.uk/?p=777#comment-49034</guid>
		<description>I am surprised that no one has read the paper by Jalili and Abbasi 1961, it is a study on ethylmercury poisoning in rural Iraq in the 1950s and is the best example of this toxins effect on humans.  Papers written after this one deal with the developmental effects of mercury.  For more mercury information refer to the &quot;Mercury study report to congress&quot; written in 1997 it is an excellent source of information on mercury.  It is free, and on the EPA website I believe</description>
		<content:encoded><![CDATA[<p>I am surprised that no one has read the paper by Jalili and Abbasi 1961, it is a study on ethylmercury poisoning in rural Iraq in the 1950s and is the best example of this toxins effect on humans.  Papers written after this one deal with the developmental effects of mercury.  For more mercury information refer to the &#8220;Mercury study report to congress&#8221; written in 1997 it is an excellent source of information on mercury.  It is free, and on the <span class="caps">EPA</span> website I believe</p>
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		<title>By: Joseph</title>
		<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/#comment-49026</link>
		<dc:creator>Joseph</dc:creator>
		<pubDate>Sun, 20 Apr 2008 19:20:51 +0000</pubDate>
		<guid isPermaLink="false">http://leftbrainrightbrain.co.uk/?p=777#comment-49026</guid>
		<description>&lt;i&gt;It may be a small amount, but it’s still a real amount. Since you can’t produce a toxicity level for Thimerosal, you can’t scientifically argue, nor can you quantify the odds that it won’t have any effect on a small percentage of children. The reality is that you and I just don’t know.&lt;/i&gt;

If we&#039;re talking about the same &quot;thimerosal hypothesis&quot; then the dose matters quite a bit. Maybe you&#039;re talking about a different &quot;thimerosal hypothesis&quot; which I&#039;m unaware of The &quot;thimerosal hypothesis&quot; I&#039;m referring to says that an &quot;autism epidemic&quot; occurred due to an increase in the total thimerosal dose per child from about 70 mcg to about 180 mcg. Perhaps you&#039;ve renounced the idea of an autism epidemic, or at least of an autism epidemic having anything to do with thimerosal?</description>
		<content:encoded><![CDATA[<p><i>It may be a small amount, but it&#8217;s still a real amount. Since you can&#8217;t produce a toxicity level for Thimerosal, you can&#8217;t scientifically argue, nor can you quantify the odds that it won&#8217;t have any effect on a small percentage of children. The reality is that you and I just don&#8217;t know.</i></p>
<p>If we&#8217;re talking about the same &#8220;thimerosal hypothesis&#8221; then the dose matters quite a bit. Maybe you&#8217;re talking about a different &#8220;thimerosal hypothesis&#8221; which I&#8217;m unaware of The &#8220;thimerosal hypothesis&#8221; I&#8217;m referring to says that an &#8220;autism epidemic&#8221; occurred due to an increase in the total thimerosal dose per child from about 70 mcg to about 180 mcg. Perhaps you&#8217;ve renounced the idea of an autism epidemic, or at least of an autism epidemic having anything to do with thimerosal?</p>
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		<title>By: Joseph</title>
		<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/#comment-49025</link>
		<dc:creator>Joseph</dc:creator>
		<pubDate>Sun, 20 Apr 2008 19:09:18 +0000</pubDate>
		<guid isPermaLink="false">http://leftbrainrightbrain.co.uk/?p=777#comment-49025</guid>
		<description>What I said before raises another question. The in-vitro studies of thimerosal where it is found that it damages brain cells or mitochondria, I don&#039;t believe indicates it only does so if the cells are from specific types of people. So why doesn&#039;t every single person who gets vaccinated with a TCV become  brain damaged? That by itself seems to put any claimed implications of said in-vitro studies in serious doubt.

Of course, it&#039;s not hard to imagine why those in-vitro studies don&#039;t translate well to real life, but that&#039;s another way of thinking about the issue.</description>
		<content:encoded><![CDATA[<p>What I said before raises another question. The in-vitro studies of thimerosal where it is found that it damages brain cells or mitochondria, I don&#8217;t believe indicates it only does so if the cells are from specific types of people. So why doesn&#8217;t every single person who gets vaccinated with a <span class="caps">TCV</span> become  brain damaged? That by itself seems to put any claimed implications of said in-vitro studies in serious doubt.</p>
<p>Of course, it&#8217;s not hard to imagine why those in-vitro studies don&#8217;t translate well to real life, but that&#8217;s another way of thinking about the issue.</p>
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		<title>By: Kev</title>
		<link>http://leftbrainrightbrain.co.uk/2008/04/mitochondria-autism-and-thimerosal/#comment-49005</link>
		<dc:creator>Kev</dc:creator>
		<pubDate>Sun, 20 Apr 2008 05:56:14 +0000</pubDate>
		<guid isPermaLink="false">http://leftbrainrightbrain.co.uk/?p=777#comment-49005</guid>
		<description>_&quot;Not a lot is not a scientific measurement.&quot;_

Of course its not. But then neither is &#039;some unspecified amount that&#039;s never been established to do anything in terms of autism causation&#039;.

_&quot;Additionally, you’ve switched to neurological disorder, when all Dr. Poling was suggesting was that the level of mercury could result in a mito dysfunction not a neurological disorder.&quot;_

I was referring to the idea that a trace amount of thiomersal could cause autism.</description>
		<content:encoded><![CDATA[<p><em>&#8220;Not a lot is not a scientific measurement.&#8221;</em></p>
<p>Of course its not. But then neither is &#8216;some unspecified amount that&#8217;s never been established to do anything in terms of autism causation&#8217;.</p>
<p><em>&#8220;Additionally, you&#8217;ve switched to neurological disorder, when all Dr. Poling was suggesting was that the level of mercury could result in a mito dysfunction not a neurological disorder.&#8221;</em></p>
<p>I was referring to the idea that a trace amount of thiomersal could cause autism.</p>
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