Dr. Dean Jones testified on the topic of oxidative stress in the morning of Day 9 of the Thimerosal-only portion of the Omnibus Autism Proceedings hearing. Dr. Jones is a professor at Emory University. He received a Nobel fellowship to do research in molecular toxicology in Stockholm. He is currently a peer reviewer for the journals Toxicology, Nutrition, Science, and Nature Methods. He also has been the chair of a “study section” at the NIH, as such it was his job to oversee peer review process of grant applications.
He is the recipient of grants to do research. One of his major grants for looking at oxidative stress in cell nuclei. He is one of the asst. program directors for a $22 million award from the NIH for translational research. Dr. Jones oversees two labs at Emory, one is his own research lab focusing on redox chemistry. He lectures on nutritional biochemistry, pharmacology and metabolism and has written many articles on sulfur metabolism, and he estimates that he has written over 100 original research articles on oxidative stress.
Dr. Jones testified that sulfur is the 5th most common element in biological systems and sulfur is ubiquitous in living systems. All this sulfur beneficially affects how our bodies deal with heavy metals.
The following is more of my rough transcription of what Dr. Jones said as he was examined by Ms. Renzi. Words in parentheses are my summary of what was said, the rest is more of an attempt to get what was said word-for-word. Keep in mind, there is a lot more than this. I haven’t tried to transcribe all the testimony by Dr. Jones wherein he explains a lot about what Glutathione is and details the reasons for his conclusions about Dr. Deth’s hypothesis and the idea that thimerosal in the doses contained in the vaccines given to even the tiniest babies ever could do anything vaguely like harm:
Ms. Renzi: …. Glutathione does more than just detoxify heavy metals, is that correct?
Dr. Jones: Glutathione has a very important role in metabolism. It is the major thiol. (It’s a major) sulfur containing chemical…. maybe 1/3 of the total sulfur (in the body is found in glutathione) the most abundant thiol.
Ms. Renzi: What is the role of glutathione in the body?
Dr. Jones: … The one that has probably received the most attention in the past 50 years is the function of glutathione as an anti-carcinogen. Glutathione is used to counter reactive chemicals that would otherwise cause mutations in the DNA and cause cancer. A little over 50 years ago it was recognized that many chemicals we are exposed to are activated in the body to reactive chemicals, the most central way that the body gets rid of these is by reacting these with glutathione. Glutathione is the most anticarcinogenic chemical we have in our body.
It is also an antioxidant….Hydrogen peroxide is produced in the body all the time, about a pound a day of oxygen consume, about 1% of that is converted to hydrogen peroxide- a large portion of that is eliminated by glutathione.
…there is a coenzymatic function of glutathione. One of the main ways we get rid of formaldehyde is through a catalytic action, involves using glutathione as a catalyst. The glutathione is not used up (in doing that).
Ms. Renzi: Deth’s hypothesis is thimerosal containing vaccines disrupt sulfur metabolism and causes autism. …
And Based upon your knowledge and research in the area of sulfur metabolism and glutathione do you have an opinion as to whether thimerosal at the doses administered in thimerosal containing vaccines can significantly affect sulfur metabolism.
[This is about the 22 minute mark.]
Jones: What the data show is that the dose of thimerosal (under discussion) will not affect in a significant way, sulfur metabolism.
Renzi: Why is that?
Dr. Jones: (He gives the amount of sulfur in a human body. He gives estimated total body glutathione.) 1 millimolar (is) 1000 micromolar. (He gives the amount of sulfur in sulfur containing foods a typical baby would eat: 500 micromoles per kg of body weight.) … We have a huge total thiol content in the body.
Ms. Renzi: (In your scenario that compares sulfur exposure to mercury exposure from vaccines,) how did you calculate the thimerosal dose?
I took the cumulative dose (that) was 180 mcg. I rounded it up (apparently to 200 mcg). (I calculated it as if) that were given all at once to a 1kg child, so that would be a two pound child. This is a very conservative way to look at this, the exposure would probably be six-fold lower than this. If you calculated it this way that would be equivalent to one micromole per kg of body weight. The more realistic would be 0.1 micromole per kg. The cumulative dose of thimerosal is considerably less than that daily intake of sulfur amino acids would be… 2000 fold lower than the total body thiol.
Renzi: Do food items also contain reactive materials that our body use glutathione to deactivate.
Johnson: … if we look at the amount of reactive materials in a 8 oz glass of 2% cows milk that number is 21,700 nanomoles. If you assume that a child would consume 4 oz in a serving would be the equivalent of 10 micromoles. One 4 oz serving would contain more than 10 times as much of the reactive materials (as is in the estimated 200 mcg of mercury from thimerosal.)
Renzi: The amount of reactive materials (in those common foods are) above that cumulative dose in a thimerosal normally administered over a 6 month period.
(1 hour 36 minutes)
Dr. Jones: (summing up) … at 4 critical sites in this scheme the pieces don’t fit together that that’s a plausible hypothesis and plausible mechanism that changes in sulfur amino acid is a cause of autism
Ms. Renzi: So, the data that Dr. Deth presented actually in formulating his hypothesis doesn’t support his hypothesis is that correct? …
Yes. … Slide 28 is Dr. Deth’s slide 41… What I think that the data show, uh, you know, to me fairly clearly in, you know, that that there really is not appropriate evidence, this is just not, the data, saying that the dose of thimerosal is enough to alter the sulfur metabolism, this is not, not established by the data. And similarly if you had a perturbation in the sulfur even if a very minor effect happened it really wouldn’t be of a magnitude that one could consider that that is the cause of oxidative stress. I think you have to conclude that this is not established, either, the second point. And finally then if you look at the subsequent aspects of that the variations, the oxidative stress, there’s a normal variation in oxidative stress and that the magnitude of effects are really not appropriate, and in fact the mechanisms that he’s drawn can not account for changes in the methionine synthase activity and the in vitro data he’s provided without in vivo data supporting it, really you have to conclude that this step in the pathway is also not established. That is the oxidative stress to the methionine synthase.
…And so from that summary, from my standpoint there really is no plausibility to this hypothesis at all. It’s what I would consider a, a scaffold without a building. there’s a lot of components to it but it really doesn’t have the strength, solidity of being solid science, of being reasonable or plausible. …
So, this is my final slide, slide 29 … I think in terms of the overall, you know, my overall consideration of this:
I think the point one is the cumulative dose of thimerosal is too low to cause the magnitude of effects on glutathione metabolism that would be required to conclude that there’s any likelihood of effect there. It’s not plausible.
Point two, the natural variations are greater than one would expect from the low dose of thimerosal that are present in thimerosal containing vaccines.
The third point, … if you did have an effect, you’d have to conclude that the low non-toxic dose would probably be protective, because that would be activating protective mechanisms that ubiquitously occur.
Fourth, the in vitro studies show that thimerosal disruption of metabolism is probably occurring under non-specific conditions–ones that were you simply have the cellular conditions set up so that you are going to be disrupting lots of things–that you are not going to be giving any specificity. That’s simply because they are at irrelevant concentrations, irrelevant amounts.
I have to conclude that the data really don’t support this hypothesis that there is an effect on the glutathione system that’s causing oxidative stress and that that’s the cause of autism.
Ms. Renzi: Thank you.
Special Master Vowell (addressing PSC lawyer, Mike Williams): Are you prepared to begin cross examination or would this be a good time for a break?
Mr. Williams: I would very much enjoy a break, if that would be alright with you.
One can only imagine how much Mr. Williams needed that break.
I’m running out of adjectives to describe how thoroughly the dead parrot hypothesis has been demolished by the Department of Justice’s experts up to this point. I would not like to be Dr. Deth or even Dr. Wally. There work in cell cultures was described as basically not worthy of publication and it puzzles experts on how it got past peer review. Even the Petitioner’s Steering Committee’s own experts are doing serious damage to their own hypotheses from my observation, via sloppy testimony, bad evidence, citing what amount to speculative essays by absolute non-scientists “published” in non-peer reviewed magazines, experts with unusual ties to unusual funding sources, shaky sources for “data” in testimony that most would consider plagiarized because the real source was not cited, self plagiarism from previous reports, inflated–bordering on fabricated–credentials, extreme lack of expertise in the area where they are testifying, lack of preparation, and a lack of agreement and coherence between the petitioners own experts’ stories. Oh, and they keep bringing up new stuff, new ideas, new papers at the very last minute, which is just not done.
And … I have to ask, if the PSC lawyers were confident in what they were presenting, would they really need to be insulting to the experts for the DoJ? Seriously. Dr. Jones started to get impatient with the way Mr. Williams was badgering him on the cross examination and acting as if he, Jones, should already know what was in a paper that Mr. Williams just handed to him a minute previously, one of those last minute introductions of “evidence” that is totally out of bounds, normally. What I keep hearing on and off from the PSC lawyers, is a tone of voice that implies, “You’re just an idiot, aren’t you? You don’t know this???” Maybe that’s how lawyers are supposed to talk, but I didn’t hear it coming from the DoJ lawyers on cross examination of the PSC experts. The Special Masters have been very generous. I hope the Special Masters can see what a flimsy structure the arguments are that the PSC has constructed.
I hope parents who buy into the whole vaccine/heavy metal causation hypothesis and its accompanying “biomed” insanity are listening to these hearings because they will see how they’ve been led around by the nose by “experts” using big words and “healers” making big promises. I also hope that people don’t ever avoid vaccinating their children just out of fear of autism or vague fears of “toxicity.” The stuff to fear is not the vaccines. The stuff to fear is the sometimes deadly germs that vaccines can help protect their children from.