Comments on: John’s Hopkins FAQs: The meaning of neuroinflammatory findings in autism http://leftbrainrightbrain.co.uk/2009/11/johns-hopkins-faqs-the-meaning-of-neuroinflammatory-findings-in-autism/ Autism news and opinion Wed, 23 May 2012 16:15:50 +0000 hourly 1 http://wordpress.org/?v=3.0.1 By: passionlessDrone http://leftbrainrightbrain.co.uk/2009/11/johns-hopkins-faqs-the-meaning-of-neuroinflammatory-findings-in-autism/#comment-73896 passionlessDrone Sun, 17 Jan 2010 15:02:03 +0000 http://leftbrainrightbrain.co.uk/?p=3646#comment-73896 Hello friends - This paper, <a href="http://www.ncbi.nlm.nih.gov/pubmed/20074449?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1" rel="nofollow">Autism spectrum disorders and mastocytosis.</a> was published the other day and I thought I'd post a link as it was discussed here previously. Theoharides claims a roughly 1/10 prevalance of autism in patients with mastocytosis. I've yet to read the entire paper, but hope to soon. - pD Hello friends –
This paper, Autism spectrum disorders and mastocytosis. was published the other day and I thought I’d post a link as it was discussed here previously.

Theoharides claims a roughly 1/10 prevalance of autism in patients with mastocytosis. I’ve yet to read the entire paper, but hope to soon.

– pD

]]> By: passionlessDrone http://leftbrainrightbrain.co.uk/2009/11/johns-hopkins-faqs-the-meaning-of-neuroinflammatory-findings-in-autism/#comment-70573 passionlessDrone Tue, 01 Dec 2009 01:11:25 +0000 http://leftbrainrightbrain.co.uk/?p=3646#comment-70573 Hi Mike Stanton - <blockquote>Theoharides is a well qualified researcher with an impressive publication record. However very few of those publications are directly related to autism and those that are are literature reviews rather than clinical studies. Perhaps his new paper will remedy that. Even so, he does have a commercial interest in the success of this theory and I would like to see it supported by disinterested researchers.</blockquote> Very nice find and I agree with your assessment. It does seem that Theoharides has been studying his primary point of interest, mast cells, for over three decades. Damn, though, I didn't know he had so many articles in Nature and Science! He claims a 1/10 prevalance of autism in his patients with mastocytosis. Here is a presentation by him regarding mast cells and autism. I got through about 1/3 of it earlier today. I have a lot of thoughts concerning activated microglia and the Hopkins FAQ that I'm trying to articulate well. Sorry for derailing the thread. - pD Hi Mike Stanton –

Theoharides is a well qualified researcher with an impressive publication record. However very few of those publications are directly related to autism and those that are are literature reviews rather than clinical studies. Perhaps his new paper will remedy that. Even so, he does have a commercial interest in the success of this theory and I would like to see it supported by disinterested researchers.

Very nice find and I agree with your assessment.

It does seem that Theoharides has been studying his primary point of interest, mast cells, for over three decades. Damn, though, I didn’t know he had so many articles in Nature and Science! He claims a 1/10 prevalance of autism in his patients with mastocytosis.

Here is a presentation by him regarding mast cells and autism. I got through about 1/3 of it earlier today.

I have a lot of thoughts concerning activated microglia and the Hopkins FAQ that I’m trying to articulate well. Sorry for derailing the thread.

– pD

]]> By: dr treg http://leftbrainrightbrain.co.uk/2009/11/johns-hopkins-faqs-the-meaning-of-neuroinflammatory-findings-in-autism/#comment-70562 dr treg Mon, 30 Nov 2009 22:31:37 +0000 http://leftbrainrightbrain.co.uk/?p=3646#comment-70562 Touche Touche

]]> By: Mike Stanton http://leftbrainrightbrain.co.uk/2009/11/johns-hopkins-faqs-the-meaning-of-neuroinflammatory-findings-in-autism/#comment-70553 Mike Stanton Mon, 30 Nov 2009 21:47:04 +0000 http://leftbrainrightbrain.co.uk/?p=3646#comment-70553 Dr Treg believes that <i>There is often room for scepticism when scientists use the upper case for certain words or sentences in their reports/conclusions.</i> and proceeds to capitalize Tregs! pD I am interested in the disclosure statement in <a href="http://www.immunobiotics.com/pdf/autism/AutismTrendsPharmSciAug08[1].pdf" rel="nofollow">an earlier paper</a> by Theoharides detailing his patents. <i>US patents No 6,624 148; 6,689 748; 6,984 667; 7,115 278; 10/811 825 and EPO 136577 (awarded to T.C.T.) cover methods and compositions for blocking mast-cell activation. These patents and the dietary formula NeuroProtek1, which could be used for autism, have been licensed to Algonot, LLC (www.algonot.com).</i> Theoharides is a well qualified researcher with an <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&term=mast%20cell%20theoharides&linkpos=1&log$=related_query" rel="nofollow">impressive publication record.</a> However very few of those publications are directly related to autism and those that are are literature reviews rather than clinical studies. Perhaps his new paper will remedy that. Even so, he does have a commercial interest in the success of this theory and I would like to see it supported by disinterested researchers. Dr Treg believes that

There is often room for scepticism when scientists use the upper case for certain words or sentences in their reports/conclusions.

and proceeds to capitalize Tregs!

pD
I am interested in the disclosure statement in an earlier paper by Theoharides detailing his patents.

US patents No 6,624 148; 6,689 748; 6,984 667; 7,115 278; 10/811 825 and EPO 136577 (awarded to T.C.T.) cover methods and compositions for blocking mast-cell activation. These patents and the dietary formula NeuroProtek1, which could be used for autism, have been licensed to Algonot, LLC (www.algonot.com).

Theoharides is a well qualified researcher with an impressive publication record. However very few of those publications are directly related to autism and those that are are literature reviews rather than clinical studies. Perhaps his new paper will remedy that. Even so, he does have a commercial interest in the success of this theory and I would like to see it supported by disinterested researchers.

]]> By: passionlessDrone http://leftbrainrightbrain.co.uk/2009/11/johns-hopkins-faqs-the-meaning-of-neuroinflammatory-findings-in-autism/#comment-70528 passionlessDrone Mon, 30 Nov 2009 16:44:46 +0000 http://leftbrainrightbrain.co.uk/?p=3646#comment-70528 Hi Dr. Treg - From Dr. DeWitts page: <blockquote>We believe that autoreactive T cells lead to neuronal damage and suspect that mast cells alter the permeability of the blood-brain barrier to allow infiltration of autoreactive T cells into the brain (we are working with Dr. Jared Brown to develop a mast cell project).</blockquote> This is a pretty interesting statement. Theoharides is pretty big on mast cell involvement with autism; in fact, he has a paper coming out in a month or so that shows extremely highly elevated rates of autism in a population with mastocytosis. I'd love to dig deep into this subject but don't have the time now. - pD Hi Dr. Treg –
From Dr. DeWitts page:

We believe that autoreactive T cells lead to neuronal damage and suspect that mast cells alter the permeability of the blood-brain barrier to allow infiltration of autoreactive T cells into the brain (we are working with Dr. Jared Brown to develop a mast cell project).

This is a pretty interesting statement. Theoharides is pretty big on mast cell involvement with autism; in fact, he has a paper coming out in a month or so that shows extremely highly elevated rates of autism in a population with mastocytosis.

I’d love to dig deep into this subject but don’t have the time now.

– pD

]]> By: dr treg http://leftbrainrightbrain.co.uk/2009/11/johns-hopkins-faqs-the-meaning-of-neuroinflammatory-findings-in-autism/#comment-70502 dr treg Mon, 30 Nov 2009 08:31:06 +0000 http://leftbrainrightbrain.co.uk/?p=3646#comment-70502 There is often room for scepticism when scientists use the upper case for certain words or sentences in their reports/conclusions. Certainly other researchers apart from Johns Hopkins are looking at the effects of prednisolone and other immunosuppressants on regulatory T-cells and macrophages/dendritic cells/microglia in inflammatory diseases including autism often with conflicting results. http://www.jimmunol.org/cgi/content/abstract/183/2/841 http://www.ingentaconnect.com/content/ben/cst/2009/00000004/00000003/art00006 http://cjasn.asnjournals.org/cgi/content/abstract/4/10/1661 Assistant Professor DeWitt`s study of TREGS in autism is awaited. http://www.ecu.edu/cs-dhs/pharmacology/DeWitt09.cfm http://www.youtube.com/watch?v=9Pg7ETKZN74 Christina Hift M.D., F.A.A.P., Clinical Assistant Professor of Pediatrics at the Albert Einstein College of Medicine describes prednisone as appearing "to be one of the only medications that has a high rate of success in treating the underlying cause of speech loss or lack of speech in autism." http://www.aheadwithautism.com/research.html There is uncertainty with regards the answer to the questions 1. "Do TREGS control the microglial activity in inflammatory disorders such as autism" as there are few studies on this matter. http://www.abdserotec.com/animation/t-cell/ 2. "Can immunosuppressants such as prednisone lead to significant clinical improvement in autism?" as there are no double-blind controlled clinical trials of prednisone in autism. It is an old adage in medicine "never to say never" - especially in the upper case. There is often room for scepticism when scientists use the upper case for certain words or sentences in their reports/conclusions.
Certainly other researchers apart from Johns Hopkins are looking at the effects of prednisolone and other immunosuppressants on regulatory T-cells and macrophages/dendritic cells/microglia in inflammatory diseases including autism often with conflicting results.
http://www.jimmunol.org/cgi/co...../183/2/841
http://www.ingentaconnect.com/.....3/art00006
http://cjasn.asnjournals.org/c...../4/10/1661
Assistant Professor DeWitt`s study of TREGS in autism is awaited.
http://www.ecu.edu/cs-dhs/phar.....Witt09.cfm
http://www.youtube.com/watch?v=9Pg7ETKZN74
Christina Hift M.D., F.A.A.P., Clinical Assistant Professor of Pediatrics at the Albert Einstein College of Medicine describes prednisone as appearing “to be one of the only medications that has a high rate of success in treating the underlying cause of speech loss or lack of speech in autism.”
http://www.aheadwithautism.com/research.html
There is uncertainty with regards the answer to the questions
1. “Do TREGS control the microglial activity in inflammatory disorders such as autism” as there are few studies on this matter.
http://www.abdserotec.com/animation/t-cell/
2. “Can immunosuppressants such as prednisone lead to significant clinical improvement in autism?” as there are no double-blind controlled clinical trials of prednisone in autism.

It is an old adage in medicine “never to say never” – especially in the upper case.

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