I’ve generally stopped countering the misinformation by the Age of Autism blog. They are pretty much irrelevant now that they lost their star power, now that Jenny McCarthy and Jim Carrey have dropped out of the picture. They still cause harm, but on a much smaller scale than in the past.
That said, I recently saw one of the Age of Autism contributors in an online discussion. And as is typical, the conversation devolved into throwing around the usual tired arguments. For example–
The notorious Offit 10,000 vaccine paper (we might add 10,000 vaccine doctrine) was written to be re-assuring to parents. The reality is that 1 vaccine might kill an infant. But what is the rhetorical effect of saying 10,000 vaccines (or 100,000 vaccines originally) are “theoretically safe”. It really says that if we give them 10 at time and hundreds over a childhood it is no big deal. What we are really on to here is the hit and run strategy. It doesn’t matter egregious the effects of the ever extended and mandated schedule are you can always insist that it wasn’t vaccines (which are theoretically safe). And you can flood the media with people like you deriding the experience of actual rather than theoretical families who have found that products are not necessarily that safe after all. And you can claim that everything you say is thoroughly scientific (hoho).
Now, this is a new way to misrepresent what Dr. Offit wrote. So far off that one wonders if the author of the comment (one John Stone) has actually read the original. He claims that the Offit paper’s claim is ” It really says that if we give them 10 at time and hundreds over a childhood it is no big deal.”
Nope. Not even close.
Studies on the diversity of antigen receptors indicate that the immune system has the capacity to respond to extremely large numbers of antigens. Current data suggest that the theoretical capacity determined by diversity of antibody variable gene regions would allow for as many as 109 to 1011 different antibody specificities.38 But this prediction is limited by the number of circulating B cells and the likely redundancy of antibodies generated by an individual.
A more practical way to determine the diversity of the immune response would be to estimate the number of vaccines to which a child could respond at one time. If we assume that 1) approximately 10 ng/mL of antibody is likely to be an effective concentration of antibody per epitope (an immunologically distinct region of a protein or polysaccharide),39 2) generation of 10 ng/mL requires approximately 103 B-cells per mL,39 3) a single B-cell clone takes about 1 week to reach the 103 progeny B-cells required to secrete 10 ng/mL of antibody39 (therefore, vaccine-epitope-specific immune responses found about 1 week after immunization can be generated initially from a single B-cell clone per mL), 4) each vaccine contains approximately 100 antigens and 10 epitopes per antigen (ie, 103 epitopes), and 5) approximately 107 B cells are present per mL of circulating blood,39 then each infant would have the theoretical capacity to respond to about 10 000 vaccines at any one time (obtained by dividing 107 B cells per mL by 103 epitopes per vaccine).
The paper merely states that an infant’s immune system can respond to the antigens in 10,000 vaccines.
So here is the challenge to Mr. John Stone (who wrote the above comment), the Age of Autism blog (where he writes, but not the above comment.) and everyone else who claims that the 10,000 number is wrong.
Prove the claim is wrong.
What in the above calculation is wrong? Is it the biology? The assumptions? The math? State clearly what is inaccurate in that calculation.
The answer is that many who cry out about “10,000 vaccines” haven’t read the paper. Or they have and they don’t understand it. Or, in rare cases, they understand it and are willfully trying to use it to scare people.
I have posted this challenge before on various internet discussions. And it is always, and I mean always, met with silence.
Notice that Dr. Offit doesn’t say that an infant can take 10,000 injections. But that “each infant would have the theoretical capacity to respond to about 10 000 vaccines at any one time (obtained by dividing 107 B cells per mL by 103 epitopes per vaccine).” I.e. that an infant can respond to the challenge posed by the antigens in 10,000 vaccines.
But that’s not scary. And fear and doubt is what people are trying to create when they claim that Paul Offit’s 10,000 vaccine paper is “notorious”.
So, go ahead anyone and everyone that uses the 10,000 vaccine statement to scare people about vaccines. Back up your complaint. I’ve been waiting for years and expect to continue waiting.
by Matt Carey