Comment on study: Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder

23 Nov

Missed this one from earlier this year. A study that looked at both MMR uptake and thimerosal exposure from infant vaccines. Guess what? “No convincing evidence was found in this study that MMR vaccination and increasing thimerosal dose were associated with an increased risk of ASD onset”


The abstract is below.

Why do I suspect that this is not included on “vaccine information” websites like the so-called “National Vaccine Information Center”, or “Dr. Bob’s” new site? Oh, because it doesn’t scare parents about vaccines, that’s why. And they can’t even blame the CDC or drug manufacturers for putting out a biased study (well, they can, they will, because they always do).

This study was done by Japanese academics. I’m sure some connection to Big Pharma will be produced to discount the fact that this study tells us what every other actual study on MMR and thimerosal and autism has said.

Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder.
Uno Y1, Uchiyama T2, Kurosawa M3, Aleksic B4, Ozaki N5.
Author information
This case-control study investigated the relationship between the risk of Autism Spectrum Disorder (ASD) onset, and early exposure to the combined Measles-Mumps-Rubella (MMR) vaccine and thimerosal consumption measured from vaccinations in the highly genetically homogenous Japanese population.

Vaccination histories at 1, 3, 6, 12, 18, 24, and 36 months from birth were investigated in ASD cases (189 samples), and controls (224 samples) matching age and sex in each case. Crude odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to determine relationship between MMR vaccination and ASD. The differences in mean values of the thimerosal dosage between cases and controls were analyzed using an unpaired t-test. MMR vaccination and thimerosal dosage were also investigated using a conditional multiple-regression model.

There were no significant differences in MMR vaccination and thimerosal dosage between cases and controls at any age. Furthermore, the ORs (95% CIs) of MMR vaccination and thimerosal dosage associated with ASD in the conditional multiple regression model were, respectively, 0.875 (0.345-2.222) and 1.205 (0.862-1.683) at age 18 months, 0.724 (0.421-1.243) and 1.343 (0.997-1.808) at 24 months, and 1.040 (0.648-1.668) and 0.844 (0.632-1.128) at 36 months. Thus, there were no significant differences.

No convincing evidence was found in this study that MMR vaccination and increasing thimerosal dose were associated with an increased risk of ASD onset.

Copyright © 2014 Elsevier Ltd. All rights reserved.

Autism Spectrum Disorder; Case–control study; Environmental factors; Measles–Mumps–Rubella vaccine; Risk factor; Thimerosal

By Matt Carey

9 Responses to “Comment on study: Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder”

  1. Dorit Rubinstein Reiss November 23, 2015 at 23:55 #

    If you missed this, you may have missed the Polish study too:

    Early exposure to thimerosal-containing vaccines and children’s cognitive development. A 9-year prospective birth cohort study in Poland.
    Mrozek-Budzyn D1, Majewska R, Kiełtyka A.
    Author information
    The controversial topic of the early exposure to mercury is regarding ethylmercury, which is present in the thimerosal-containing vaccines (TCVs). The objective of this study was to determine the relationship between the early exposure to TCVs and cognitive development in children during the first 9 years of life. The cohort included 318 children vaccinated in an early period (neonatal and up to 6 months) against hepatitis B and diphtheria-tetanus-pertussis (DTP) using formulation with or without thimerosal. The children’s development was assessed using the Fagan test (6th month of life), the Bayley Scales of Infant Development (BSID)-II (12th-36th month), the Raven test (5th, 8th year), and the Wechsler Intelligence Scale for Children (WISC-R) (6th, 7th, 9th year). Results were determined by multivariable linear and logistic regression, adjusted to potential confounders. Children exposed and not exposed to TCVs in the neonatal period had similar outcomes of cognitive-developmental tests; only the results of BSID-II at the 36th month and WISC-R at the 9th year were significantly higher for those exposed to TCVs. Developmental test results in children exposed to TCVs up to the 6th month of life also did not depend on thimerosal dose. Conclusion: TCV administration in early infancy did not affect children’s cognitive development.

    The one that found that thimerosal in vaccine leads to higher IQ.
    A living example that spurious results happen.

    • strawman January 21, 2016 at 19:54 #

      Dorit, please explain the Hanna Poling case. Ours was similar but we are not neurobiologists so we were ignorant He was officially diagnosed with autism at age two. We were Ignorant about thimerosal and mitochondrial disorder. Urine metabolites indicated mitochondrial disorder but at the time and even now his doctors dismiss it since there is no cure. Injecting a newborn without even knowing the complete status of his health or history is unconscionable. His apgar score mentioned his color was gray. He was 10 lbs and had a large head and after many hours of labor he was delivered by C-section. All of these studies about “no link” are meaningless because all children are individuals and we don’t know enough about the brain and neurotoxins. I have heard that autism numbers did not go down after 2001 but instead increased but the increase is due to better diagnosing. Consider this:
      Public Release: 16-Oct-2013
      New cases of autism in UK have levelled off after 5-fold surge during 1990s

      BMJ-British Medical Journal

      • reissd January 22, 2016 at 17:47 #

        Thimerosal has nothing to do with mitochondrial disorders. In a recent case, the court found that there was no evidence mitochondrial disorders are related to vaccine injury. I address that – and the relationship to the Poling concession – here:

        The second part is a little confusing. Why do you think only more recent rises in autism diagnoses are because of better diagnosing, rather than seeing the increase in total as a function of broadening the definition and better diagnosing?

    • strawman January 22, 2016 at 18:11 #

      Dorit, thank you for your reply. It proves you can’t believe everything you read on the internet. If he has a mito disorder than thimerosal was not the trigger. I finally understand that the increase in autism diagnosis in the 90’s was due to broadening the definition and better diagnosing. I have been reading about oxidative stress. Thanks again for setting me straight.

  2. brian November 23, 2015 at 23:57 #

    In an earlier study, the same group similarly concluded that there is no convincing evidence that either MMR or “increasing the number of vaccine injections [is] associated with an increased risk of ASD.” [Vaccine. 2012 Jun 13;30(28):4292-8.]

  3. Roger Kulp November 24, 2015 at 01:55 #

    One wonders if these pointless vaccine studies are ever going to stop.Such a waste of valuable research time,money,and other resources.Please Safe Minds,and the rest of your ilk,stop funding this stuff,and just go away.

    • AndersG November 25, 2015 at 10:55 #

      There is a comment on PubMed by Janet Kern that questions some of the statsitics in the paper. I do not have access to the full paper, but can anyone who has comment?

      • brian November 25, 2015 at 16:43 #

        Re: Comment on Uno et al.

        It seems that Kern caught an error in one of the tables, and that the error was corrected by the authors.

        Note that these same authors had earlier found (in a paper in which no such error was noted, and which apparently evaluated exactly the same 189 cases and 224 age- and sex-matched controls that were compared in the more recent publication) that MMR is not associated with increased risk of ASD. [Vaccine. 2012 Jun 13;30(28):4292-8.]

      • brian November 25, 2015 at 18:40 #

        Re: Janet Kern’s comment on Uno et al.

        Kern apparently pointed out an error in Table 2 of the the 2015 paper. [Vaccine. 2015 May 15;33(21):2511-6.] As Kern notes in her comment, the journal corrected that mistake.

        Note that that 2015 Vaccine paper was in large part a reprise of an earlier article in the same journal: in their 2012 paper, the authors apparently evaluated exactly the same 189 cases and 224 age- and sex-matched controls that they again featured in the more recent publication. In the earlier paper, as in the more recent work, there was no increased risk of ASD associated with receipt of MMR. [Uno Y et al. The combined measles, mumps, and rubella vaccines and the total number of vaccines are not associated with development of autism spectrum disorder: the first case-control study in Asia. Vaccine. 2012 Jun 13;30(28):4292-8.]

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