Archive | MMR RSS feed for this section

No, Wakefield’s Autistic Enterocolitis Does Not Exist

2 Sep

Listen to Andrew Wakefield talk for a while and he will tell you his work has been replicated. Usually claiming replicated multiple times and around the world. Since he says it, it gets repeated by his supporters in online discussions.

For those who get dragged into those discussions, here is another paper to reference. This one takes on the idea that there is a bowel disease specific to autism. Wakefield’s “autistic enterocolitis”

People have looked and, guess what, it isn’t there. Yes, autistics get bowel disease. Being autistic doesn’t prevent bowel disease. The fact that some do, indeed, get bowel disease isn’t what Wakefield claimed. He claimed a “new syndrome”.

It doesn’t exist.

Here’s the abstract. The group is reputable and, in fact, has expressed sympathetic views towards Wakefield.

Evaluation of Intestinal Function in Children With Autism and Gastrointestinal Symptoms.

OBJECTIVE:
Alterations in intestinal function, often characterized as a “leaky gut,” have been attributed to children who are on the autism spectrum. Disaccharidase activity, intestinal inflammation, and permeability were analyzed in 61 children with autism and 50 nonautistic individuals with gastrointestinal symptoms.

METHODS:
All patients had duodenal biopsies assayed for lactase, sucrase, maltase, and palatinase activity. Intestinal permeability was evaluated by rhamnose/lactulose test and measured by high-performance liquid chromatography-mass spectrometry. Intestinal inflammation was evaluated by fecal calprotectin and lactoferrin levels using enzyme-linked immunosorbent assay and histology.

RESULTS:
Some children with autism had mild levels of mucosal inflammation on intestinal biopsy. Disaccharidase activity was not different in autistic and nonautistic individuals. Fecal calprotectin and lactoferrin were similar in both groups. Differences between lactulose and rhamnose recovery and lactulose/rhamnose ratio in urine were not statistically different in patients with and without autism.

CONCLUSIONS:
The present study supports the observation that children with autism who have symptoms of gastrointestinal disorders have objective findings similar to children without autism. Neither noninvasive testing nor endoscopic findings identify gastrointestinal pathology specific to autism, but may be of benefit in identifying children with autism who have atypical symptoms.

If you are getting ready to write, “but they might not have seen enough kids to find one with autistic enterocolitis”, according to Wakefield, most of the kids his team tested had his “new syndrome”. If that were true, this team would have found it.

Add this to “MMR causes autism” as one of the failed ideas of Andrew Wakefield. Not that he will ever admit it.


By Matt Carey

Andrew Wakefield. He’s not anti-vaccine. He just thinks “This is a deliberate eugenics program, a deliberate population-control program.”

19 Aug 1471357679-pmx090116-conspiracycruise19

Remember the “ConspiraSea Cruise”? Well another story has come out on it, this time from Popular Mechanics: I Went on a Weeklong Cruise For Conspiracy Theorists. It Ended Poorly.

I feel bad for grabbing one line from the story, as the whole story is quite good. But for now, let’s just take a look at this one paragraph:

“Your bodies are owned by Big Pharma,” he said. “It’s turning into a science-fiction movie.” The audience gasped and shook their heads in disbelief. “This will be the end of the United States of America.” During the Q&A portion, Wakefield added, “This is a deliberate eugenics program, a deliberate population-control program.”

“This is a deliberate eugenics program, a deliberate population-control program.”

I’ve been told this was in response to a question about vaccines possibly being a part of a eugenics program.

This is the sort of statement Mr. Wakefield typically has avoided making public. It’s the sort of statement that plays well on the “ConspiraSea Cruise”, but in more reasoned company is clearly wrong and irresponsible. It’s the sort of statement that goes against the image of Wakefield as the “legitimate scientist who is wronged for ‘just asking questions'”.

I have no idea how Mr. Wakefield defines “anti-vaccine”. Readers here will recognize that I rarely use the term. So, let’s continue in that mode. Let’s not refer to him as “anti-vaccine”. He is strongly, and irresponsibly, and using misinformation, “anti-vaccine-program”. How can someone who believes that vaccines are “a deliberate eugenics program, a deliberate population-control program” be anything else?

1471357679-pmx090116-conspiracycruise19


By Matt Carey

Polly Tommey, she won’t judge autism parents who murder, but judges Fiona O’Leary for just criticism

12 Aug

Readers here may recall this recent article: Polly Tommey won’t judge parents who murder their disabled children. That’s part of the problem. We discussed this video where Polly Tommey tells us about how she won’t judge parents who murder their autistic children.

In a later video she used the “I haven’t walked in their shoes” excuse.

Since then Ms. Tommey, through her film distributor Cinema Libre Studio, has threatened to sue an autism parent. An autistic autism parent. Fiona O’Leary: Cinema Libre Studios and Andrew Wakefield’s Vaxxed team threaten autistic autism mom.

In a more recent video she has posted she flat out judges Fiona O’Leary.

“She’s a pain, that woman”.

“She claims to be on the spectrum. In that case I feel bad for you.”

“She hasn’t seen the film” (Fact check–Fiona has, indeed, seen Vaxxed.)

Here’s a word for Polly Tommey:

Hypocrisy

hy·poc·ri·sy

The practice of claiming to have moral standards or beliefs to which one’s own behavior does not conform; pretense.

Kill a kid: you will not be judged.

Criticize Polly Tommey: you will be judged.

Someone has her priorities seriously out of order. And it’s not Fiona O’Leary.


By Matt Carey

Irish Examiner: US film studio threatens to sue autism-rights advocate

26 Jul

As I wrote about yesterday, Andrew Wakefield’s “Vaxxed” team, led by distributor Philipe Diaz of Cinema Libre Studio, threatened Fiona O’Leary (an autistic adult who is also the parent of autistic children). Well, it looks like the story has been picked up by the Irish Examiner.

The article starts:

A US film studio has threatened to sue an Irish autism-rights advocate if she continues to speak out against its controversial anti-vaccine documentary, Vaxxed: From Cover-Up to Catastrophe,.

West Cork-based mother, Fiona O’Leary, who wants to block the film’s release in Ireland and Britain, said she was outraged to receive a legal letter from California-based Cinema Libre Studios over the weekend.

Read the rest at US film studio threatens to sue autism-rights advocate


By Matt Carey

Del Bigtree crosses the line: tells Vaxxed audience “Now’s the time” for guns.

19 Jul

Del Bigtree helped Andrew Wakefield produce a faux documentary called Vaxxed. Vaxxed has been discussed here and elsewhere a great deal, but here is a review from Science Based Medicine if you are looking for more details (Andrew Wakefield’s VAXXED: Antivaccine propaganda at its most pernicious).

The team that made Vaxxed has been using the screenings as a platform to give personal appearances. Below is a clip from one of those personal appearances. I would encourage you to watch for yourself:

In case you couldn’t watch or skipped the video, here are the concluding statements of this particular speech by Mr. Bigtree:

“Anyone who believes in the right to bear arms. To stand up against your government. I don’t know what you were saving that gun for then. I don’t know when you planned on using it if they were going to take control of your own body away.

It’s now. Now’s the time.”

We need to stop here and do what neither Polly Tommey nor anyone in that audience had the guts to do: stand up to Del Bigtree and say No! No, this is not the time to use guns.

This is no joking matter. Bigtree’s comments are at best beyond irresponsible and at worst a call for armed violence.

Whatever was in Bigtree’s mind, why didn’t anyone speak out against this? There was nervous laughter when Bigtree made his call to arms so people can’t claim they didn’t hear or didn’t understand what he was suggesting. Here’s the Facebook post with the full video. There are over 1500 comments. And I can’t find one that says, “No, Del, we reject a call to violence.”

I want to keep this short, but I will repeat myself for emphasis: Del Bigtree crossed the line in a big way with his comments. His comments are reprehensible.

But standing by silent while he makes these reprehensible statements is also wrong.

Ironically Del Bigtree’s facebook page has this as the top saved image:

13529029_1095999520470545_3497709959753327622_n

You fans of Del Bigtree, you need to walk the walk. Stop patting yourselves on the back for being “brave” and show that you are indeed brave individuals. Disavow these statements.

Del Bigtree, you need to dial this back. You need to apologize and take back these statements.

By Matt Carey

Andrew Wakefield to Grace Hightower: “your family’s life [has] been blighted by autism”

22 Apr

One thing I have noticed over the years–those who are antagonistic towards vaccines are quite willing to use the disability community, but are rarely willing to offer us respect. Consider Andrew Wakefield, who introduced one book with a fictionalized account of a mother murdering her autistic child. He framed it as an act of love by the mother. Or his film, “who killed Alex Spourdalakis”. Alex was an autistic young man with extraordinary needs. Andrew Wakefield tried to make Alex’s life  into an episode for his (now failed) reality TV show. When Alex was brutally murdered by his mother and another caregiver, Wakefield took his footage and made a film.  It was an apology piece for the murders, using Alex as a hammer to attack mainstream medicine.

So now we have Wakefield apparently leaking his celebrity emails and showing again his misunderstanding for and contempt of autistic people. This is discussed at length by ScienceMom at JustTheVax: Paging De Niro and Hightower…Wakefield isn’t really in it to help autistics

I’ll just quote one email:

On Mar 29, 2016, at 9:18 AM, Andy Wakefield wrote:
Grace, whatever may have happened – and I guess I will never know – in truth my heart goes out to you and Bob. Not only has your family’s life been blighted by autism, but you have experienced some of the relentless and ruthless pressure that has been my life for as long as I can remember.
In truth and healing
Andy

Andy Wakefield
Director
Autism Media Channel

Just to be clear, Mr. Wakefield:

My child is not a blight. On me, my family or on anyone else.
My child is not blighted.
My life is better for my child. Challenges, struggles and all.

Just to be clear Ms. Hightower: if you didn’t respond to Mr. Wakefield in a way similar to the above, shame on you. But, while I am at it, shame on you for promoting this man and his damaging message. If you believe him, take a moment and ask yourself: if he’s lying (he is) how much harm has he caused to me, my family and mostly my son?

When you dehumanize people Mr. Wakefield, you make it easier for people to murder my child. You made it easier for people to abuse my child. You make it easier for people to disrespect my child. It is already a struggle to get adequate supports and assistance. How much will people be willing to help the “blighted”?

My child doesn’t need the charity of pity. My child needs the helping hand of respect.

And you, Mr. Wakefield, are in the way of that.

People ask me why do I spend my time countering your misinformation. This is why.


By Matt Carey

Why do people have to see Vaxxed to criticize it? Wakefield’s own description of us tells us Vaxxed is bogus.

21 Apr

Andrew Wakefield got an interview on Fox to defend his film Vaxxed (the video and transcript are at Fox Provides Platform For Discredited Doctor To Claim CDC Is Hiding Evidence That Vaccines Cause Autism). And he’s shooting back at his critics: if you haven’t seen the film you can’t criticize it. It’s doubly ironic. First Wakefield’s team didn’t send out DVD’s to the press, and, second, many critics have seen the film. But the “you can’t comment on the film because you haven’t seen it” is the same argument he used with his horrible “Who Killed Alex Spourdalakis” film. (For those who are unfamiliar with it, it’s a film where Wakefield defends a mother and caregiver for the brutal murder of an autistic young man.) That film was worse than I expected it to be. And I was expecting bad.

Wakefield describes his film in the Fox interview. And just based on Wakefield’s own words, we can see that the film is inaccurate.

Wakefield:

Dr. William Thompson comes forward and says they have known for 14 years that MMR vaccine is causally associated with autism and they have covered it up.

This is wrong. First, the study Wakefield is talking about can not show causality. This sort of epidemiology can show researcher “here’s a place to look for causality”. Anyone who has been in this field for 20 years, like Andrew Wakefield, would know that. ]

But let’s get more to the point–Thompson didn’t say that they showed a causal connection.

From a statement by William Thompson:

The fact that we found a strong statistically significant finding among black males does not mean that there was a true association between the MMR vaccine and autism-like features in this subpopulation.

no “true association” means it doesn’t show causality.

Wakefield goes on:

And so the film, it’s his words, it’s his opinion, it’s his documents that really carry the message of this film that there has been a huge cover-up which has put millions of American children in harm’s way and it was totally unnecessary.

But as we’ve just seen, the key point of the film is precisely not Thompson’s words or opinion.

Wakefield appears to be using William Thompson as a sock puppet. We are told what Wakefield seems to either believe or wants us to hear. And with the claim that it’s not Wakefield doing the telling but Thompson.

But Wakefield’s own words about Vaxxed don’t match Thompson’s own words.

But per Wakefield people can’t criticize the film.

For whatever it’s worth, it’s not just William Thompson who stated that the study doesn’t show a causal connection. Even Brian Hooker, a colleague of Wakefield, didn’t claim a causal connection in his re-analysis of the CDC data. Here’s as close as Brian Hooker gets to claiming causality in his (now retracted) paper:

Additional research is required to better understand the relationship between MMR exposure and autism in African American males

Not “we found a causal connection”, but effectively “someone should test this for causality”. Frankly I don’t think this was a moment of intellectual honesty from Brian Hooker as much as pragmatics: referees know that this study can’t show causality so they would have rejected Hooker’s paper had he tried.

Thompson’s documents don’t show a causal connection either. I’ve made them public so people can check what is in them. Wakefield hasn’t. But Wakefield asks people to “make up their own mind”. The documents don’t show a “huge cover-up”. They don’t show “millions of children in harm’s way”.

Simple check of facts here: The “huge cover-up” putting millions of American children in harm’s way”, shouldn’t we address this? Wakefield is discussing one preliminary result in the CDC study: African American boys vaccinated before age 3. In all other groups, the study (confirmed by Brian Hooker) shows what all the other MMR studies show: no indication of an MMR/autism link. This point, by the way, isn’t stressed in Vaxxed. Even when they bring in autism families, they are mostly white.

But, back to this result. Leaving aside that Vaxxed isn’t accurate, shouldn’t we be concerned? Well let’s do some checking. Brian Hooker in his paper is saying that African American boys are 3.36 times more likely to be diagnosed autistic if they get the MMR vaccine before 36 months. If that is due to a real causal connection, we should easily see that in other data. MMR uptake is generally comparable by race. So even though African Americans are a minority in the U.S., 3.36 is high enough that some indication of a risk would have shown up in one of the other autism/MMR studies. But let’s not just handwave like that. Let’s check directly: is the autism prevalence higher in African Americans? Boys are roughly 4 times more likely to be diagnosed as girls, using Hooker’s 3.36 increased risk for African American boys (and if I’ve done my math correctly) African Americans should have an autism prevalence 2.9 times higher than Caucasians.

2.9 times higher autism prevalence. That’s big. We would see that on autism prevalence studies easily.

The CDC recently released an autism prevalence estimate. And they show that African Americans are less likely to be diagnosed.

Estimated ASD prevalence was significantly higher among non-Hispanic white children aged 8 years (15.5 per 1,000) compared with non-Hispanic black children (13.2 per 1,000), and Hispanic (10.1 per 1,000) children aged 8 years.

Yes, African Americans are less likely to be diagnosed (about a factor of 0.85). Again, using the data that Wakefield claims shows a “causal” connection between the MMR and autism, we expect 2.9 times higher prevalence. The facts just don’t match up with Wakefield’s claims.

The fact that autistic people from racial/ethnic minorities or low income families are less likely to be diagnosed is a problem true autism advocates are trying to fix. Many are not receiving the appropriate services and supports. But that’s what real autism advocates are working on, not Andrew Wakefield.

So, we have a film that by comparing Andrew Wakefield’s own description with the facts is inaccurate. But per Andrew Wakefield people can’t criticize Vaxxed if they haven’t seen it. That’s a bit of a logical fail on Mr. Wakefield’s part. Not like we have a shortage of those.


By Matt Carey