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Green Our Vaccines Eve – Dr Jeffrey Brent

3 Jun

On the eve of the ‘green our vaccines‘ rally, I thought it might be interesting to share a ten minute or so segment from the Autism Omnibus.

Giving evidence is Dr Jeffrey Brent:

Jeffrey Brent, M.D., Ph.D. is a sub-specialty board certified medical toxicologist. He is an active member of the medical school teaching faculty and is an attending physician on the clinical pharmacology/toxicology consultation service at the University Hospital. Currently he holds the rank of Clinical Professor of Medicine at the University of Colorado Denver. Dr. Brent has a long list of publications, virtually all related to clinical toxicology. He is senior editor of Critical Care Toxicology: The Diagnosis and Management of the Critically Poisoned Patient and serves as Editor-in-Chief of Toxicological Reviews, a major international state-of-the-art review journal devoted to human toxicology.

Dr. Brent is the former President of the American Academy of clinical Toxicology, the largest organization in the world devoted to this discipline. Currently he serves as a member of the Board of Directors of the American College of Medical Toxicology.

We pick up testimony around five and half hours into day 15. I’ve transcribed directly from the audio, so please forgive minor errors. Emphasis is Brent’s, inserts are marked [].

Q: Dr Mumper discussed today some key aspects of chelation therapy….as a medical toxicologist do you see any reason for the chelation to remove mercury from either Jordan King or William Mead in these cases?

Absolutely not….there is no test in medicine that is more valid for for assessing mercury toxicity than an unprovoked urine mercury concentration.

[For Jordan King and William Mead]…their unprovoked urine concentration is exactly in the normal range.

On the other hand, they have been chelated. And the justification for that chelation with regard to mercury comes from what you see in the right hand column where in both cases, 4 out of 5 provoked examples have been…uh…increase urine mercury. Well, you’re supposed to have increased urine mercury with provoked examples! Therefore there is absolutely no indication based here or anywhere else I saw in the medical records that suggest that there is any mercury effect in these children and therefore that was absolutely no reason to chelate them for any mercury related reason.

Q: Dr Mumper also testified today to seeing an increase in lead levels in children and that chelation may help with the adverse effects from lead. Is there any scientific or medical basis for that statement?

It is true that chelation therapy is the appropriate therapy for lead toxicity. However, the records do not reflect any lead toxicity in the case of either of the two children at issue here, Mead or King. Neither of them have had an elevated blood lead level and a blood lead level is the ‘gold standard’ test for lead toxicity. Because, contrary to testimony that was given earlier today [Dr Mumpers – KL], blood lead remains elevated and it will be elevated for years in children that have lead toxicity. It equilibrates with tissues and if there’s high tissue burden there will be high blood burden.

Q: So you disagree with Dr Mumper that the blood levels would only test for acute toxicity?

Thats absolutely wrong. So there was no indication therefore for treating these two children with a chelator for any lead effects.

Q: Is there any other accepted tests for lead toxicity, other than blood?

Blood is the ‘gold standard’ and there are no other accepted tests in medicine now that we can routinely get blood/lead levels.

Q: Was there anything about the levels you observed in the medical records [of either King or Mead – KL] post chelation that would cause you to think that these were extraordinarily high levels of excretion upon chelation?

No. You always expect to see levels in the urine bump post-chelation. It would happen to any one of us. There are no validated reference ranges post chelation, thats why they’re not used in medical practice – there is no valid way of using them and in fact if you look at these two children they had mild increases in urine/lead excretion as I recall but they were nothing different than what you would normally expect to see if you gave a chelator to them.

Q: And you’ve given chelators to a lot of children?

I’ve chelated a number of children.

A: There’s nothing here that would be out of the ordinary – from your experience – absent, even in the absence of a standard reference range.

Well, in truth we don’t (?) urine/leads because the ‘gold test’ is blood/lead so I haven’t looked at many urine/leads in children that I have chelated. So I can’t speak to that in my experience. But I have seen a number of patients now come to me because of these ‘doctor’s data‘ type of laboratories which are based on urines – chelated urines – and they always have high leads in their chelated urines and I tell them ‘well, lets just do the gold standard test, lets get a blood/lead level and so far, 100% of the time they’ve been normal.

Q: Are the post chelation mercury levels in either of these two boys in excess of what you would see…or in excess – I take it there’s no standard reference range…?

No standard reference range. You do tend to see small increases, they’ve had minor increases in their mercury excretion over the reference ranges over the non-provoked. It was certainly not very dramatic and certainly well within the range of what you would expect to see. For example if you look at the studies that I cited where they were studying chelators and they were looking at the effect of the chelator on urine/mercury excretion.

Now thats a valid time to do a post chelation mercury – if you want to study the effect of the chelator. And if you look at the normal controls in those studies, when they give them a chelator you do see some increase in the urine/mercury excretion and its a moderate increase and its really not very different than what we saw in these children [King and Mead – KL]

Q: Have you chelated children for lead or mercury toxicity?

Actually, both.

Q: And under what circumstance did you chelate for mercury toxicity?

I’ve had a number, but probably the most common and the most dramatic relates to the fact that I live in Colorado and in the Rocky Mountain area there people who are still panning for Gold…..[they extract the gold from ore using liquid mercury]…and to get rid of the mercury [afterwards] they will heat it. In their house. In their kitchen. When you volatilise mercury like that [it gets into the air]….and I’ve had a number of families have become profoundly mercury poisoned.

Q: So when Dr. Mumper said that she saw ‘mobilisation’ of heavy metals by chelation and then assumed that the chelation was beneficial – do you agree with that statement?

No, I think what you see is – you give a chelator, you look in the urine and there’s more than in the non-chelated reference range is for the metals in the urine and its what you would normally expect. It tells you nothing about mobilising stores of heavy metals.

Q: Dr Mumper also talked about supplements. And those supplement were referred to increase Glutathione to treat mercury toxicity. Do you agree that that therapy is warranted in cases?

Glutathione? No. Supplemental glutathione to treat mercury toxicity has no validity at all.

Dr. Rust testifies in the Autism Omnibus Hearing

22 May

Today Dr. Robert Rust testified in the thimerosal-only causation portion of the Autism Omnibus Proceedings. Dr. Rust also testified in the Hazlehurst case regarding the combined MMR-thimerosal causation hypothesis. You can find Dr. Rust’s testimony in the Hazlehurst case in the Day 3 transcript from that case. Today is “Day 8” of the thimerosal portion so you can look for the “Day 8” mp3 files on the US Federal Court website.

Dr. Rust has some impressive credentials. He is the Thomas E. Worrall, Jr. Professor in Epileptology and Neurology, and Professor of Pediatrics at the University of Virginia. He had a residency in Pediatrics at Yale University and in Child Neurology and neurochemistry at Washington University in St. Louis. He also had a fellowship in Neurochemistry, Neonatal Neurology, and Brain Metabolism, at Washington University. A University of Virginia website says that he has clinical interests in epilepsy, headache, neonatal neurology and degenerative disorders.

Dr. Rust had a lot of material to cover in his testimony. It seemed to me that he was trying to cover a semester or two’s worth of neurodevelopment and neurophysiology in a couple of hours, trying to keep it simple enough for the needs of the court, and yet detailed enough to make some critical points about how neurons, microglia and astroglia work and discussing what is known about regression in autism and what might cause it. He also discussed some of the particulars of the medical records of William Mead and Jordan King. Their main DAN! doctor is Dr. John Green III of Oregon. Dr. Green is a favorite DAN! doctor as was made clear in the testimony by Jordan King’s mother. She said something like seeing Dr. Green was “invitation only.” No doubt. Many of the lab tests discussed were ordered by Dr. Green, and many of the therapies the boys had were ordered or administered by Dr. Green, including one very traumatic IVIG infusion Mr. Mead described his son enduring.

Bogus lab tests are a huge problem in autism “biomedical” therapies. Not that all of the lab tests used by all DAN! (Defeat Autism Now!) doctors are bogus, but it sure seems like many of those that parents share with the public are highly questionable lab tests such as hair analysis for heavy metals, and urine heavy metals lab tests from one particular lab that was mentioned several times in the testimony. For instance, an image of one of these very lab tests was used as an illustration at the top of a blog entry on a certain autism hysteria promoting group blog recently.

When Dr. Mumper testified she commented about how one of the boy’s lab results had this extremely high level of tin while the other metals were in a normal range. (Keeping in mind that the “normal ranges” on these tests are nearly arbitrary and don’t have much to do with real world levels of anything in healthy or sick autistic children.) Dr Mumper acted as if this was not that weird and she said a couple of times, at least, that when they see such a high level of tin in a child she will ask the parents if the kids are eating a lot of toothpaste or drinking a lot of juice from “juice boxes”. She didn’t offer a specific therapy for “tin intoxication”, whereas if mercury had been that high they no doubt would have all been sobbing over the horror of it all. At any rate, Dr. Rust made an interesting point that high levels of tin are almost unheard of and to get a high enough level of tin to affect health, it basically takes a decade or two of working with tin every day where the tin is exposed to heat and is creating tin vapor and a worker is inhaling it. This didn’t reflect well on the quality of that lab’s tests, or on Dr. Mumper’s ability to think critically about such things as lab test results, in my opinion.

The following is a very rough transcript of one portion of Dr. Rust’s testimony that I found very interesting. I don’t know if the Dept. of Justice lawyer was Ms. Renzi, but I think it was, so I’m using her name for the time being. [Edit: The DoJ lawyer was Ms. Esposito, not Ms. Renzi. This portion of the audio transcript is found in the 2nd file on day 9 the following part is found around a 30 minutes into that recording). The words I added in parentheses are not direct quotes but gives the meaning of what was said. I can’t type that fast and so as I was taking notes I didn’t transcribe portions of it word for word, but got the gist.

Ms. Renz Esposito: I’d like to discuss some of the treatments given to these children.

Esposito:: (Can you tell us if) IVIG therapy (is helpful in autism?)

Rust: t’s been tried along with it’s cousin corticosteroids, but no improvement has been seen bahaviorally, functionally or with EEG.

Esposito:: (Can you tell us about the) supplements (given to William Mead and Jordan King?)

Rust: We don’t hear about most of them probably, to the extent that there is data (these supplements don’t help), to the extent that parents tell us what they are using.

Esposito:: Secretin?

Rust: Secretin was found not to be effective

Esposito:: Chelation?

Rust: I’ve seen no evidence that chelation is helpful in this setting…. (recalls when kids with lead poisoning were chelated in a clinic/hospital where he work) considerable pain it caused. Children would be screaming on the way into chelation.

Esposito: Saunas?

Rust: Saunas can help with headaches and stress and tensions but in autism there is nothing to sweat out except some of the notions about treatments that have been offered to the child.

Esposito:: Dr. Green’s therapies…. (for William Mead or Jordan King) included an implantation enema, ideally with a colonic delivery system, using maternal fetal [fecal?] supernate…

Rust: So far as I know that the approach has been around since Roman times, …. used to be a regular feature of childbirth.

Esposito:: Feeding a child fermented vegetables?

Rust: …(doesn’t change autism)…

Esposito: Earthworm eggs?

Rust: No known benefit that I’m aware of. (The discussion changed to something about herbal treatments.) I had a patient with seizures, the parents gave a Chinese herbal (medicine). The Chinese botanical was interesting. We were astonished (the child had a striking improvement in seizures) , we sent a sample of it to a lab and found out it was phenobarbital.

Esposito: Charcoal?

Rust: (No reason to think it would help)

Esposito: Oral baygam (oral immune globulin)?

Rust: I have no information about that.

Esposito: Valtrex?

Rust: I don’t know any reason to think it would work. (a little later he added that Valtrex is a drug used to treat herpes infections.)

Esposito:: Are you familiar with Eskimo oil?

Rust: (slightly amused) No I haven’t heard of that.

Esposito: Actos?

Rust: (I don’t know of any benefit for autism.)

Esposito: If there were a report of improvement would you extrapolate that there was a cause of autism.

…

Esposito: Is it standard practice to prescribe something to patients and then sell it to them?

Russ: (A doctor’s obligation to the patient) is to listen without repeating their problems… (not to sell the patient treatments) … to keep an office of Amway products. It trades on the prestige we have and the reliance that the patients have on us. It is one of the most grave violations of our code of ethics.

Esposito: Do you prescribe these things?

Russ: No …

Esposito: Do other neurologists prescribe these things?

Russ: No …

The “implantation enema” as I understood it, that was recommended by Dr. Green for one of the boys
was a “fecal enema“.

Specifically, again as I understood it, what was recommended was to take some of the boy’s mother’s feces and mix it with water and infuse that into the boy’s colon or something. From Dr. Rust’s response I got the feeling that he didn’t understand that this particular enema wasn’t just a water enema, but that the idea was to put the germs from the mom’s feces into the boy’s intestines.

Now I thought Dr. Rashid Buttar’s urine injections were bizarre. This one ranks right up there, though, for sheer gross-out factor. And how about those “earthworm eggs”? It’s possible that what Ms. Renzi asked about was “whipworm eggs.” Perhaps I heard what she said wrong, but it sounded like “earthworm eggs” [edit: She said “earthworm eggs”]. Taking pig whipworm eggs orally is an alternative therapy for Crohn’s disease, apparently. I remember reading somewhere that a mom asked Dr. Andrew Wakefield what he thought of giving autistic kids worms to treat their gut problems. He was quoted by that mom as saying that he didn’t think it would work for autistic children’s guts.

I encourage everyone to listen to the recordings of the autism omnibus and to read the transcripts, they are very educational. One can learn a lot about the ‘therapies’ being offered to parents of autistic children as well as some of the best of the best of the science that is known about autism. I don’t agree with everything the experts are saying, such as when Dr. Rust called autism a “disease”, but it’s still very interesting listening if you are at all interested in autism.

Autism Omnibus – Vas Aposhian

16 May

Vas Aposhian is – like Sander Greenland – an expert witness for petitioners (the families) and a professor of molecular and cellular biology as well as a professor of pharmacology.

On Day 2 and 3 he testified as to what seemed to be the main hypothesis behind the whole thiomersal/autism idea.

The basic idea is that some people are genetically predisposed to something called _mercury efflux disorder_ (plain english, they can’t get rid of mercury as well as most people can, it crosses the blood brain barrier and triggers autism). Mercury Efflux Disorder is itself an unproven hypothesis but Aposhian passionately believes in it.

He came under heavy cross exam (I won’t go through his performance whilst testifying to his own ‘side’ – we all know the basic hypothesis), that compromised a lot of day two and most of the morning of day three (the audio is released slowly so I’m a couple of days behind). The part I’m writing about today starts about an hour and a half into day three (NB: I’ve downloaded all the MP3’s and stitched them into one file).

Aposhian says that the mercury efflux hypothesis is supported by six papers:

…each piece of evidence alone leaves some doubt but taken all together the evidence implicates thimerosal/ethylmercury as the likely precipitating agent in the etiology of some of the autism spectral disorders.

Respondent counsel referred to these six papers as ‘pillars’ supporting the hypothesis. Aposhians’s pillars are:

First, Adams et al. (2007) demonstrated that teeth from autistic children contain more mercury than those from non-autistic children.

Respondent counsel asked Asphosian what he thought he could criticize about these papers he says ‘implicate thiomersal’. Regarding Adams et al, Asphosian said (and I’m paraphrasing slightly after scribbling notes furiously):

1) The number of controls should’ve been increased.
2) There were too few test subjects
3) When asked if raised mercury level was an indicator of toxicity, Asphosian answered “I don’t know”.
4) When asked if he would’ve expected mercury concentrations to vary depending on gender, Asphosian answered “Yes”.
5) When asked if Adams controlled for gender Asphosian answered, “No, he doesn’t control for gender”.
6) When asked if lead concentration of a tooth affected mercury concentration of a tooth, Asphosian answered, “I don’t know”.
7) Asphosian was asked, given the fact that the thiomersal hypothesis depended on the role of _ethyl_ mercury, what type of mercury did Adams et al measure in the teeth? Asphosian’s answer was “…did not do speciation” – in other words, he didn’t separate the types of mercury out. He recorded it all.
8) When asked if mercury levels in teeth tell you anything about amounts of mercury in the brain Asphosian replied that he didn’t know as no one had ever done that study.

These are fairly damning failings in what Asphosian’s assumptions were regarding the quality of that study. Of course, there is more wrong with the Adams paper than just the above, but these points are pretty damning. The failure to control for gender, the paucity of subjects and the fact Adams et al didn’t concentrate on ethyl-mercury raise serious questions over what exactly this study can add to the so-called Mercury Efflux Disorder.

I’ll keep appending to this post as I work through the rest of the audio.

Acceptance not denial

22 Aug

Acceptance. It is a word that some use to describe their relationship with the reality of their children, or their own, autism. We accept the fact our daughter is autistic.

For people who claim to ‘fight autism’ this acceptance is a weak passivity. An act of giving in.

This, of course, is rubbish. Those who have accepted the reality of their own or their children’s autism know that the work starts right there. We do not attempt to carry on deluding ourselves and using quack treatments such as chelation etc as shields against the reality of who our kids really are.

Parents like Brad Handley of Generation Rescue claim at one point in time that:

“autism is a misdiagnosis for mercury poisoning…..The whole notion of autism is mythical. It didn’t exist before thimerosal in vaccines”

Source

and then later say:

The argument is being spun by focusing exclusively on a single ingredient used in vaccines, Thimerosal (which is made from mercury), while forgetting to mention a number of key points about the differences between the vaccine schedule of 20 years ago and today….Thimerosal is only one of the possible ways that the vaccine schedule could be the primary trigger behind the autism epidemic…

Source

are simply in denial. When their first belief is established to be untrue, they simply move on to another belief.

From the videos I posted a link to above, Brad is asked:

Q: This therapy (chelation) is it something he (Jamie) will be on the rest of his life?

Brad’s answer is:

A: Absolutely not. Its at maximum a two year process. Probably less.

As of next month, Jamie Handley will have been undergoing various treatments for three years. His story is not, as far as I can tell, listed anywhere as a ‘recovery’ story. He is still autistic.

Brad has made no effort to go back onto TV and explain this inconsistency. This is because he cannot. It is not explainable. I will be honest. Brad and I regularly exchange verbal barbs but I often feel sorry for the Handley’s. Because of their inability to accept the reality of their sons autism they have been unable to move on. They have instead – as I think is the case with a lot of the autism/vaccine parents – sublimated their failure to ‘cure/recover’ their kids in a proxy-fight with the ND’s, the CDC, the FDA – whatever.

I read a lot of blogs from the likes of Wade, Ginger, Kim Stagliano etc and whilst I often read about their anger and I often read about their love for their kids, I never ever read about them being happy. Do they love their kids? Of course they do. Do they enjoy their time with their autistic kids? I don’t know. I don’t think so.

There is a curious emphasis in a lot of these blog posts. Take Kim Stagliano’s most infamous blog entry – The Crappy Life of the Autism Mom – in which she says:

Recovering your kids doesn’t mean denying their value as people. To the contrary, it means we are willing to devote our lives, our savings, our sanity to their improved health, development and well being.

The jarring difference between stating that she is not denying their value and describing her life as their mum as crappy never occurs to her. It is also sad beyond belief that Stagliano feels that the measure of a persons value is the suffering of their parents.

Of course, the truth is that any decent parent will devote their lives, savings and sanity to their kids well being. That is not a situation that is the sole province of autism or even disability. Just parenting. However, I think that as well as lives, money and sanity, a parent should also invest respect and reality. Sublimating a continued tilting at the windmill of your child’s condition into an increasingly dirty and violent fight against a giant conspiracy is sad. Not sad in a sneering way but genuinely sad. It must be so miserable to be simply unable to accept the reality of the nature of your child.

This inability manifests itself in some strange ways. There have been a spate of articles fairly recently which examine the possibility that older parents are more likely to have autistic kids, or that autism might be due to a ‘corrupted’ (in the medical sense) gene. The outbursts these research papers have generated on EoH are amazing:

You forgot to mention that we’re damn old TESTOSTERONE-laden refrigerator mutant moms……………Here’s more from Autism Speaks funded research. So now the theory is it’s you damn old moms with your refrigerator mutant genes that causes autism. You are such horrible people. Tsk-tsk. Clearly, you aren’t feeling guilty enough, no matter how misplaced.

Any hypothesis which mentions or refers to parents is given equally short shrift. It doesn’t take much to work out why. Even when there is no hint of ‘blame’ (as in dear old Bettlehiem) to parents, any intimation that the genetic/physical make up of parents might have something to do with causes is pounced on and denounced in increasingly hysterical overtones.

Personally I don’t see the issue. Does it matter? No, not to me. But it seems to these parents that the idea that they might carry some responsibility for the fact their kids are autistic fills them with an utter horror. Even to the point that they have to delude themselves.

Take the cases of Erik Nanstiel’s daughter and John Best’s son. Here are two fathers who regularly sing the praises of their children’s doctors (the Geier’s and Andy Cutler respectively) and yet…

When we look back at everything we pay out of pocket… and for everything we pay as a co-pay… it’s several THOUSAND a year.

Why are we still doing biomed after six long years? Because we’ve seen our daughter go from failing-to-thrive to a pretty healthy kid. From a kid who couldn’t balance her copper and zinc… who had lead and mercury through the roof, with very little glutathione… who had constant diarrhea and wouldn’t sleep at night… and terrible eyesight…

to a kid with darn-near normal mineral levels, whose heavy metals have been more than half depleted, is thriving on a good nutritional program… and whose glutathione levels are now higher than daddy’s… is sleeping wonderfully through the night and has seen a 60% improvement in her eyeglass prescription.

She’s also nearly lost her tactile-defensiveness, loves attention (much more than before), stims a LOT less… is beginning to potty train and needs less “prompting” from us for life skills that she’s learning (like using silverware at meal time and dressing/undressing, etc.)

She is still considered low-functioning…

Like Brad and I, Erik and I have also had our fair share of verbal jousts but when I read this I want to weep. How can a man who so obviously adores his daughter fail to see that which is right in front of his face? They’ve been doing biomed for six years and his daughter is still low functioning (Erik’s words). The improvements he describes have little to no bearing on autism.

I waste no pity on John Best but once again, his denial is as plain as the autistic son in front of him:

I’ve done 55 rounds of chelation safely following the advice of Andy Cutler. My son keeps improving. I advise everyone that contacts me through GR to read what Cutler has to say and consider his protocol over what some DAN doc’s say. He has answered all of my questions at no cost and this chelation for a severely autistic child is working.

Whereas today, John made a post on EoH that stated:

In the time it took me to type my last reply, my son smeared feces all over himself and his room again. I’ve long since lost track of how many hundreds of times this has happened.

By the standards of Kim Stagliano – smearing (A Crappy Life remember) equals not cured. How exactly is the chelation working for John’s son? Or is it merely a panacea for the denial that ails his dad?

Porphyrins and autism again

16 Aug

You may recall an fairly recent exchange I had with Dr Paul King (pictured below with the invention he utilises to type his many-fonted PDF’s – The Fabulous Fontographer 2000) wherein he wrote to various media people exhorting them to examine the final proof that mercury causes autism – the existence of certain Porphyrin’s in autistic kids – following on from the science (don’t laugh) of the Geier’s and Richard Lathe et al and my responses to clarify that there had been no such proof and that the authors of one of the two papers his proof rested on were the first to admit that.fontographer2000.gif

The autism and scientific world failed to fall adoringly at Dr King’s feet, possibly because either:

a) There is a vast conspiracy from the Illuminati lizard-people hiding ‘the truth’ or;
b) He’s wrong. Again.

The media world failed to fall breathlessly on Dr King’s ‘scoop’, possibly because either:

a) There is a second vast conspiracy from the press wing of the Illuminati lizard-people hiding ‘the truth’ or;
b) He’s wrong. Again.

In the meantime, parents carry on getting scammed by this latest ‘test’ for autism related mercury poisoning. If we want evidence of the sheer silliness of the whole damn thing we need only turn to the words of those that use it. The following post was forwarded to me from a member of the Autism Biomedical Europe Yahoo Group:

I’m confused by my son’s porphyrin levels and could do with help. Ran the French porphyrin tests in July 06, Feb 07 and July 07. Precoporphyrin was 30 a year ago = mecury toxic. This dropped to 18 in Feb as we chelated. We’re still chleating, but his last test showed the level was back up to 29.

His Copro levels (mercury and lead) have also gone nuts.
290 in July 06
330 in Feb 07
440 in July 07

We know that the chelators are working (urinary toxic metals show good pulls), so why are the porphyrin levels not dropping?

We live in a nice rural area with no major industry and no major source of toxic metals, so I doubt he’s picking up metals from the environment.

Weird huh? What possible explanation could there be for mercury and lead levels to not go down??? As far as I can tell, there are four:

a) Chelation doesn’t work
b) This child was never mercury poisoned
c) The Porphyrin test doesn’t work
d) Something else?

What do you think? What other explanations could there be?

DAN! Doctor Roy Kerry chelation charges

10 Jul

Thhe full set of charges against the people responsible for the death of Tariq Nadama have been posted online.

In particular, DAN! (defeat autism now) ‘doctor’ Roy Kerry has to face some very serious charges indeed.

At the time, various anti-vax apologists were saying it was a mix up of the chelating agent – that the wrong one was used. These charges kill that piece of silly rationalisation stone dead:

71. Respondent admitted to using Disodium EDTA to chelate Tariq.

72. Respondent stated to Investigator Reiser that Disodiun EDTA is the only formula of EDTA he stocks in his office.

Maybe someone could explain to me how it was a mix up when the guy only stocks one type of EDTA? Please, this I have to hear.

The list of charges against Kerry strike right at the heart of the whole quackery surrounding the use of chelation. Here’s a selection:

24. The aforesaid death of Tariq Nadama was caused by the negligence of Dr. Kerry in the following particulars:

a. In failing to make a diagnosis of the child which would justify the use of disodium EDTA;
b. In deciding to administer EDTA therapy to a child;
c. In deciding to administer disodium EDTA to “treat” autism when he knew, or should have known, that such therapy is not effective treatment for autism;
d. In administering disodium EDTA when he knew that such product was not approved by the Food and Drug Administration (FDA) for use in “treating” autism;
e. In administering the wrong type of EDTA, e.g. one that did not contain an appropriate calcium additive;
f. In ordering the administration of the EDTA in an excessive dosage and concentration;
g. In ordering the administration of the EDTA via IV push when he knew, or should have known, that said method of administration was too fast;
h. In failing to appropriately train, educate and instruct the employees of Advanced Integrative Medicine Center, Inc., who were involved in the administration of the EDTA;
i. In failing to advise the deceased’s mother, Marwa Nadama, of all of the risks of chelation therapy and all appropriate alternatives to such treatment;

This shows the autism/chelation cottage industry up for exactly what it is – dangerous psuedoscience with no regard for the children who are essentially experimented on by quacks with their parents approval.

I’m very seriously conflicted by the Nadama’s decision to sue these people. A large part of me is glad that Tariq will get justice and that RoY Kerry will join the ranks of his fellow DAN! Doctors who have injured people or who have court judgements against them. He deserves no less.

On the other hand, I think the Nadama’s bear some responsibility themselves – as do those who ‘advised’ her. The mother, Marwa, was a regular on various Yahoo/autism groups and had also posted to the (now defunct) guestbook of Autism Fair Media, Erik Nanstiel’s quack interview website. She was immersed in chelation quackery and yet her husband was a Doctor – a specialist registrar in respiratory medicine at an NHS hospital. It beggars belief that if they could find the quackery on this subject that they couldn’t find sites like mine which expose the quackery. A google.co.uk (the Nadama’s are British) for the phrase ‘autism chelation’ reveals Kathleen, Jim Laidler’s site, Stephen Barretts site and Diva’s site on page 1, this site on page 2. I simply cannot believe they did not know chelation for autism had a dubious reputation.

One thing that cannot be questioned is the dedication and skill of the investigators who have put long hours into putting this case together and (obviously) rescuing the Nadama’s from their beliefs in chelation/autism quackery. About the only positives to come out of this is the fact that the Nadama’s can now see autism/chelation for what it is. What a shame its two years and one life too late.

Geiers, Jim Adams – oh and some science

22 May

As I alluded to in my last post, there’s been a glut of publications regarding autism and thiomersal/mercury of late.

First (as they reached me) was Jim Adams latest nothing paper. Do’C has the full story but the salient points to take home about this study is that:

There’s plenty of other silliness in this paper, including citations of Geier and Geier, and a tiny sample size that produced data that I think most people would look at and ask, “so what?”. But the bottom line is this – is the authors’ conclusion supported by the data?….Neither mercury body burden nor excretion was demonstrated to be related to mercury levels in teeth, autistic children were not demonstrated to be “poor mercury excretors”, and high usage of oral antibiotics was not demonstrated to impair mercury excretion in humans.

An interesting side note – this paper was published in a journal that recently published the latest Geier twaddle. Seems like the editor likes a bit of woo. As Do’C uncovered from the editor of this journal:

“According to the literature there is a relationship between vaccines and autism.”

Which is weird as numerous literature reviews have shown the exact opposite. Either the editor is a very credulous sort or…well, no, he’s just a bloody idiot.

Now we turn to a study called ‘Lack of association between Rh status, Rh immune globulin in pregnancy and autism‘.

This study looked at:

whether mothers of children with autism are more likely to be Rh negative (Rh-) or to have received RhIg preserved with thimerosal, which is 49.6% ethyl mercury

So – do kids with autism come from a population who’s mothers had received RhIg? Thats what this study asked. The answer was:

Rh- status is no higher in mothers of children with autism than in the general population, exposure to antepartum RhIg, preserved with thimerosal is no higher for children with autism and pregnancies are no more likely to be Rh incompatible. This was also true for autism subgroups defined by behavioral phenotype, gender, IQ, regressive onset, head circumference, dysmorphology, birth status, essential, or complex phenotype

Of course, this answer didn’t suit SafeMinds Mark Blaxill. He released his usual pontificating crapola:

The study was funded by Johnson & Johnson, the largest manufacturer of RhIg products and the defendant in several lawsuits alleging a link between autism and mercury in RhIg. In an earlier 2005 poster presentation, the study authors acknowledged that the research was “supported by Johnson & Johnson Pharmaceutical Research,” but the University of Missouri press release omits mention of this conflict of interest.

Last I heard Marky, scientists don’t write press releases. Marketing depts do. As you yourself admit, when the poster version of this paper was presented, the *authors* (as oppose to the marketing dept) *did* acknowledge their funding. So, whats your point? That Missouri University Marketing dept. screwed up? Talk about a strawman.

And lets top beating around the bush here. If defendants in lawsuits can’t fund science, then why is it OK for prosecutors to fund science? If you want to go down the ‘conflict of interest’ route than that means Geier, Adams and a whole host of others who have already profited to the tune of several thousand pounds and who stand to profit even more should be equally discounted.

The press release headline falsely claims that the “Study Finds No Link Between Autism and Thimerosal in Vaccines.” The study is about Rh immune globulin, and immune globulins are not vaccines. “The headline deceives the public,” noted Mark Blaxill, director of SafeMinds. “It says an autism-mercury in vaccines link has been disproved when the research did not do so.”

Once again Marky – try and assimilate the difference between a press release and the actual paper. The paper’s abstract doesn’t mention the word vaccine until the very last sentence – and then only to point out thiomersal is also in vaccines. None of Blaxill’s point address _science_ at all. They try and make a strawman out of a press release. A press release the scientists who wrote this _paper_ no doubt had no control over whatsoever.

Blaxill then goes on to say that SafeMinds found numerous errors with the poster presentation but neglects to state what they were. Guess we should just trust them.

And if we want further verification of the non-link between the Rhogam issue then we should look no further than ‘Rh and ABO Maternal-Fetal Incompatibility and Risk of Autism‘ published in 2006 (Zandi et al) which states:

Moreover, some have speculated that RhD immune globulin injections may itself increase autism risk due to increased prenatal
exposure to thimerosal [Blaxill et al., 2004], an ethyl mercury containing vaccine preservative used in some formulations. The current findings do not support the hypothesis that the risk of autism is increased due to existing potential complications of maternal-fetal incompatibility with or without prophylaxis, nor do they appear to be consistent with the suggestion that the use of prophylaxis itself may increase risk.

Of course, SafeMinds don’t mention this as it clearly demonstrates the quackery that Blaxill wallows in.

And by the by, isn’t it incredible that for a group of people who are now claiming it never was _just_ about the thiomersal (See Brad Handley’s amazing feat of flip-flopping for details) they are certainly clinging on like grim death to that fallacy?

And hey – what about all those ‘other things’ (usually in vaccines) that ’cause autism’? Well, another recent study looked at just how well the practice of provoking reactions using a chelator (DMSA in this case) actually worked. ‘24-hour provoked urine excretion test for heavy metals in children with autism and typically developing controls, a pilot study.‘ looked at:

…Seventeen children with autism and five typically developing children were enrolled in a pilot study to test for chelatable body burden of Arsenic (As), Cadmium (Cd), Lead (Pb), and Mercury (Hg)

And the results?

Fifteen autistic children and four typically developing children completed the study. Three autistic subjects excreted one metal in greater quantity during the provoked excretion than baseline. Two of these were very close to the limit of detection. In the third case, the provoked excretion of mercury was between the upper limit of normal and lower limit of the potentially toxic reference range.

In other words – none of the kids, autistic or otherwise had clear progression into the toxic range of body burden of any metal. Three autistic kids had slightly higher results when DMSA was used to provoke than when it wasn’t. However, again, none was high enough to get into the toxic range. And as for the third autistic child, the team did one more thing:

Fish was removed from this child’s diet for greater than one month, and the provoked excretion test repeated. The repeat excretion of mercury was within the normal range.

Hilarious. The conclusion:

In the absence a proven novel mode of heavy metal toxicity, the proportion of autistic participants in this study whose DMSA provoked excretion results demonstrate an excess chelatable body burden of As, Cd, Pb, or Hg is zero.

Zero. None. Nada. Zip. Bugger all.

Lets hope that this pilot study is expanded upon and replicated.

And talking of chelation studies, Diva has some hot gossip regarding the fate of the NIMH chealtion study:

Dr. Swedo was running a chelation study at the NIMH until recently. The word, coming from a reliable source, is that the study has been shut down. This is good news, because it was a horrible study with horrible ethical problems and no legitimate scientific underpinnings. The study still appears on the clinicaltrials.gov page, but the link to the NIMH page is dead. So maybe the study rests in peace, too.

Last, but far from least, a fascinating theoretical study called ‘The Autism Epidemic: Fact or Artifact?’ has looked at the epidemic wankfest:

Using a prediction analysis, we calculate how broadening diagnostic criteria, younger age at diagnosis, and improved efficiency of case ascertainment could produce temporal trends in the incidence and prevalence of AD.

and what did they come up with?

Time trend studies report an increase as large as 11.0-fold over a 13-year period for AD. Conservative changes in the three methodological factors produced increases in the frequency of AD ranging from 2.1- to 28.8-fold

Interesting stuff. Hardly conclusive, but certainly food for thought. I can’t help but note that it comes from researchers at Columbia University. I wonder what that other CU employee Mady ‘they chewed through my skull’ Horning thinks about this study?

DAN! Doctors – The ‘other’ list

12 May

The eagle eyed amongst you will have noticed a new main menu entry at the top of this page between ‘wiki’ and ‘contact’ called DAN! Doctors.

This page contains a (worryingly long) list of some of the people with the loose honorific of ‘DAN! Doctor’ who are on the official ARI list. However, unlike the ARI list, this list will tell you the ‘other’ side of the happy-clappy hero’s of DAN! It contains notes on prosecutions, license suspensions, criminal acts and current investigations.

I can take absolutely no credit for the compilation of this list. It was handed to me by someone who wishes to remain anonymous.

This is a static page at the moment. In the near future, this page will move to its own domain and website and be driven by a database backend as it grows (as I’m sadly sure it will) however I wanted to get this up as quickly as possible.

The bottom line is that over 10% of DAN! docs (that have been looked at so far) have been in trouble. Trouble ranges from killing a patient, to paedophilia, to gross negligence to tax evasion. If you know a parent considering a DAN! doctor then make sure they read this list first. At the very least, even if they do decide to go ahead, they can avoid the bad guys.

Generation Rescue II – This Time It’s Vague

3 May

As already blogged by Steve and Orac, Generation Rescue have undergone a change in both website and message.

Up until this week and for the last two years, Brad Handley – GR Head Honcho has promoted a message quite unequivocal:

“Autism is treatable. It’s reversible. It’s nothing more than mercury poisoning,” said JB Handley, founder of Generation Rescue.

In fact, giving a reason for the redesign of the site on Orac’s blog, Brad said:

From my perspective, our website and its message have always been broader than “its ONLY mercury”…

Huh. Weird. Maybe its just me but I detect a teensy-weensy inconsistency between those two statements. Lets switch to the video!!:

And for the non-video-blessed amongst us, what Brad said was:

We immediately realised…and I think this is something that is a big surprise to people….um, that autism is a misdiagnosis for mercury poisoning.

Riiight. So let me see if I can summarise the position. When there is no science to have an informed debate about mercury, and when there’s lots of scary sounding stuff like ‘the Amish aren’t vaccinated and have no autism’ or ‘CDDS proves the epidemic’ floating around then the situation is:

“Autism is treatable. It’s reversible. It’s nothing more than mercury poisoning”.

Now that there’s no science to establish a causative link between mercury and autism, plenty of epidemiology to refute it and now that the first piece of science on the Amish has shown that actually they do vaccinate and that the penny has finally dropped, even for David Kirby, regarding CDDS’ inability to support the epidemic, what is the Generation Rescue position now? Lets see shall we?:

Our children are experiencing epidemics of ADD/ADHD, Asperger’s, PDD-NOS, and Autism. We believe these neurological disorders (“NDs”) are environmental illnesses caused by an overload of heavy metals, live viruses, and bacteria.

Wow. So we’re now no longer talking about just autism. We’re now talking about ‘neurological disorders’, including ADD/ADHD which is not even classed as being on the spectrum. That is quite some turnabout.

And look at this! Now, we’re talking about a _combination_ of causative agents: heavy metals (not just mercury any more), live viruses and bacteria.

Incredible. Makes you feel almost sorry for poor old mercury don’t it? Last week it was the Terror of the High Seas. Now it doesn’t even make it as a distinct causative agent.

The ‘live viruses’ is in there to placate the Wakefield Worshipers who think the MMR also (or in combination with mercury) caused autism. The ‘bacteria’ mention is I’m guessing a nod to the Martha Herbert theory of mold causing autism – a theory that was described thusly last time Martha took it to court:

Dr. Herbert’s publications indicate that she is an outspoken advocate of increased attention to the possibility of environmental influences. Even she, however, despite that acknowledged perspective, speaks in her published work of possibilities and potentialities, rather than of the ‘reasonable degree of medical certainty’ to which she offers to testify under oath in this case. Neither Dr. Herbert’s publications, nor any others cited, identify mold exposure as even a suspected, still less a known or proven, trigger of autism

Going back to MMR and taking a brief side journey for a minute, here’s the latest update from the Autism Omnibus proceedings. When last we left it, Petitioners had put forward one family as a ‘test case’ to see if the whole Omnibus proceeding had enough merit to proceed. There were supposed to be three. Awhile ago, the court told Petitioners to hurry up and identify the other two. They couldn’t. Respondents replied with:

The Court ordered the PSC to find two cases (similar enough to the first) to present the same basic theory of causation…..the essence of its (PSC’s) response is that it does not know of any case presenting the same causation issues as are implicated in Cedillo.

Ouch. How long has this been dragging on? Five years or something? And out of the 4,700 cases in the Omnibus no other case can be found to match the first one put forward. The only people who must be enjoying this are the lawyers.

Anyway, back to Generation Rescue.

Of particular note is the much vaunted, never seen ‘California-Oregon Unvaccinated Children Survey’ of described thusly by GR:

no studies have ever been done to compare neurological disorder (“ND”) rates of unvaccinated children to vaccinated children. We commissioned a national market research firm to survey more than 17,000 children in California and Oregon.

National market research firm eh? How very scientific. Researching popular chewing gum, researching autism causation. Yep, they’re the same. Souds very much like a a ‘convenience sample’ where people are called up. Here’s a friend of Brad’s describing what a convenience sample is and is not:

So. Not data according to David Kirby. Bummer.

Generation Rescue have also revamped their ‘Testimonials’ section. This is the section I looked at I August of last year and reached a (very) rough figure of a 5% success rate for the kids talked about on the GR site where ‘success’ is losing the diagnosis:

Out of these 59 success stories, just 3 describe their child as having been reclassified as no longer meeting a diagnosis of ASD. That’s a ‘recovery’ rate of 5%. Interestingly, one of these cases states they did not use chelation at all. That puts the Generation Rescue chelation success rate at a little over 3%.

Now, Generation Rescue have 76 ‘success stories’ (except they’re not called that any more, now they’re ‘testimonials’). Of that number, 6 claim full recovery with total loss of diagnosis. That’s a percentage of 7.8%. A heady leap of over 2%. Woo-hoo.

I was drawn to some of the newer testimonials, particularly the 6 year old ones as Meg only recently turned 7. One of them, about a girl called Liz was fascinating.

Our daughter Liz was diagnosed with low functioning autism at age three. We blamed the DTP vaccine which she had a bad reaction to. She would have very long lasting meltdowns, she would smear faeces, she would exhibit self injurious behaviour, she did not talk at all, she avoided eye contact and her only activity was that involving toys that spun. She walked on her tip toes and the doctor said she had a low IQ (below 70). We were told by mainstream medicine that she was ‘unreachable’.

Today Liz is six and after following biomedical interventions (and some other things) Liz will talk – on Christmas morning this year I went to wake her up and she said ‘good morning’ to me. She no longer smears faeces and is 99% toilet trained, she can write notes to people and knows all the letters of the alphabet and can count up to 40 unprompted. She can use a computer mouse unaided and has numerous favourite websites. The self injurious behaviour is vastly lessened, as are the meltdowns. Her eye contact is now perfect and overall her sensory issues seem 99% under control. She can drink out of a normal cup and use a knife, fork and spoon to eat whilst sitting at the table.

In so many ways, this is a different child.

Why was I drawn to this little girl so much?

Because it’s Megan’s story. I assumed a false name – Mr Clarence House – and emailed it to the Generation Rescue site. ‘Clarence’ received an email saying it was going to be on the new site which I was very happy about.

All of it is true except the name. The biomedical treatments I was talking about were multi vitamins, fish oil and a steroid inhlaer for her asthma. The ‘other things’ were love, acceptance, patience and education.

Why do this? To prove a point. You can make anyone’s story fit your own beliefs if you twist it hard enough.

Don’t worry, if it disappears I took a loving screenshot.

Brad Handley has tried to shift his goalposts as his first guess wasn’t working out. As evidenced above, he has latched on to items that are equally silly. As evidenced above he is incapable of seeing autism. He only sees mercury. As evidenced above, improvement is not limited – or even related to – detoxification of heavy metals.

Autism, Chelation and Quackery

15 Apr

Mercury Mum, Christine Heeren recently posted a video of her son receiving IV chelation on YouTube.

UPDATE: Shortly after this blog post went live, the YouTube video disappeared. Luckily I had already grabbed a copy which you can view here:

http://video.google.com/googleplayer.swf?docId=-5984127405622843714&hl=en-GB

Its a disturbing video on many levels. Heeren’s son has been undergoing chelation for seven months now and is still clearly totally autistic. During this video he is apparently writing ‘bus numbers’ down. The blog that Ms Heeren keeps (link on YouTube page) also makes it clear that her son still stims and he displays many common outward signs of autism (the scrunching up of the eyes at the start of the video reminds me of something my daughter does very much).

Heeren is subjecting her son to the Buttar protocol which should give anyone the stone cold heebie jeebies in and of itself. One patient of Buttar’s said that:

I find that Dr. Buttar talks a lot but produces little evidence.

And another said:

All the information about Dr. Buttar is still on this site but I no longer am one of his patients and I do not recommend him to any one for any reason. If you go to him for treatment BEWARE, BEWARE and read Roger Mason’s books first and go to QuackWatch.org first!

However, maybe we should take some kind of solace from the fact that Heeren’s doctor is not actually Buttar himself, only trained by Buttar. Maybe he’s a good doctor.

Heeren’s doctor is Muneer ImamMuneer Imam a shy, kind looking man wouldn’t you agree?

Well, he may well be.

In Jan 1993, the New York Office of Professional Conduct charged Muneer Imam:

…with gross negligence, gross incompetence, negligence on more than one occasion and failure to maintain adequate records.

The Hearing Committee sustained the charges of negligence on more than one occasion, incompetence on more than one occasion and failure to maintain adequate records. The Hearing Committee found Imam guilty of careless practice, lack of attention to detail and failure to appreciate the severity of patient illness

The incidents have included at least one death of a patient under the care of Imam.

The Hearing Committee (incredibly in my view) said he could probably be rehabilitated and laid out a plan of rehabilitation.

This all took place under Imam’s work at an ER. Imam no longer does ER work. I asked a medical friend about why that might be and xyr response was:

Since he no longer seems to do ER work, I imagine he settled a med mal claim for deceased patient A, and his insurer refused to write coverage for ER work and no hospital would cover him

Is this really someone any parent would want to trust with the kids life? A doctor found to be incompetent, negligent and who doesn’t pay attention to detail?

This inability to pay attention to details certainly seems to be playing out on Heeren’s video. Here is Imam’s nurse (a Vietnam vet called Nick) fitting the IV for a course of chelation.

No sterile

When I showed this to my medical friend xyr response was horrified:

WTF is this alleged nurse doing starting an IV without gloves??? What happened to sterile technique? Have they lost their minds?

and

What is this alleged nurse doing using that frigging tiny gauge needle???

It seems that the chelation protocol Buttar uses specifies a 22 gauge butterfly needle, not the tiny one seen in the video. There are good reasons why:

…..because this is the easiest to use for employees with no medical training who call themselves “chelation technicians.” The tiny needle also serves to prevent patients from killing themselves by increasing the drip rate when they’re sick of sitting around for hours. Increasing the drip through a 22 gauge butterfly needle should (in theory) burst the vein before delivering Endrate at a lethal rate. Clever stuff.

While almost everyone can start an IV with this tiny needle, it’s dangerous to use for chelation because if patients get into trouble you want a large bore needle inserted in case you need to administer drugs and fluids for treatment or god forbid, resuscitation. Starting a second IV with an appropriate size needle in a patient in circulatory collapse from shock is difficult and sometimes impossible. The daunting prospect of starting an IV in the jugular makes sane physicians do everything to avoid being in this position.

Administering a bolus of calcium gluconate to counteract hypocalcemia through this tiny needle can result in a swollen hand (when the IV infiltrates) attached to a dead patient.

So – Nick the Nurse also has incompetence issues.

At one point in this video I thought I had gone mad. Did my ears deceive me or did I really hear Nick the Nurse describe how they also chelated with vinegar and garlic? I rewound the video. Yep, he said it alright. Vinegar and Garlic. I could say ‘wow’ or ‘holy crap’ to express my incredulity after hearing that but really, no words do it justice. They are chelating this poor lad with Garlic and vinegar.

And why? What for? First test

Here is Heeren’s son’s first ever lab report (click the image to get a bigger one).

Let’s remember that these lab reports are all part of the quack culture and I suspect are frequently exaggerated to get the parent to use more of their treatments. If even these results are exaggerated then I’m dumbfounded. Everything except Aluminium and Lead are within normal ranges. And even those two are just barely in the elevated range.

It is on this basis that Heeren decided to start chelating her son using a doctor described as medically negligent and incompetent under the tender care of a ‘nurse’ who doesn’t know the protocol he is supposed to be using and who is actively putting this boy (and presumably others) in potential danger.

Oh and don’t forget the garlic and vinegar. Thanks Rashid, thanks Muneer, thanks Nick.

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