A true autism hero

7 Jan

This story is nothing to so with vaccines or Andrew Wakefield but all to do with a genuine autism hero. A man who risked – and lost – his own life to help an autistic friend:

on Monday afternoon Dunn was ‘doing what he often did: teaching a student a life lesson by walking him across the street to buy a soda.’ According to police, a public transit bus was turning left and hit Dunn, while barely missing the student. Illinois State Police are investigating ‘initial witness statements that Dunn pushed the child out of harm’s way.’

Aside from the weirdness of referring to a 19yo as a child, this report genuinely moved me. Amid the sordid crap coming from the autism-vaccine community about their hero, its uplifting to read a story about a genuine man with genuine motives who did nothing except exemplify the human spirit. I hope my autistic child meets many like Thomas James Dunn throughout her life and I hope his family can take solace from the fact that their father/husband/son was and is a true hero.

Andrew Wakefield: the last gasps of a desperate man?

7 Jan

In his interview on Anderson Cooper 360 last night, Andrew Wakefield made some amazing claims against Brian Deer, claiming Brian Deer is part of some vast conspiracy. He wants to distance himself from the word, but that’s what he’s claiming with phrases like “He’s a hit man, he’s been brought in to take me down”, “It’s a ruthless pragmatic attempt…” “Who’s paying this man, I don’t know” and a claim that Mr. Deer is paid by the Association of British Pharmaceutical Industries.

Anderson Cooper has Brian Deer on tonight:

http://i.cdn.turner.com/cnn/.element/apps/cvp/3.0/swf/cnn_416x234_embed.swf?context=embed&videoId=health/2011/01/07/ac.autism.brian.deer.cnn

Brian Deer throws down the gauntlet and challenges Andrew Wakefield to sue him. Wakefield has already brought forth one case against Mr. Deer–and he forced to pay Brian Deer’s legal fees. Mr. Wakefield brought forth a lengthy complaint to the UK’s press complaints commission, only to abandon it without attempting to prosecute the complaint.

He also goes through a number of Mr. Wakefield’s attacks and shows that they are false.

Here’s the transcript from the Brian Deer interview:

(BEGIN VIDEOTAPE)

COOPER: Brian, overall, Wakefield is denying all of — all of the — the evidence that you have put forward in — in this — in this “British Medical Journal” report. What do you make of his — his — his defense?

BRIAN DEER, INVESTIGATIVE JOURNALIST, “THE SUNDAY TIMES OF LONDON”: Well, two things.

One, what else can he do, where else can he go but to deny it, and to make up even more tall stories about me, suggesting that somehow I’m in cahoots with the drug industry or governments or whoever else. He’s been at that one for years.

Secondly, these revelations are not just my revelations. They have been checked, exhaustively, by editors of “The British Medical Journal,” who have peer-reviewed it, who have gone back into the data individually and checked back and forth to have been sure that what I have said is accurate. So, it’s not just me.

So, I think it’s just the — the last gasps of a desperate man, really.

COOPER: I want to go over some specific things, because I think it’s important to be very specific with these allegations and with his response.

I asked Andrew Wakefield last night to respond to your report and the — the “British Medical Journal” report, which calls his study — quote — “an elaborate fraud.”

Here’s what he said.

(BEGIN VIDEO CLIP) WAKEFIELD: I have read his multiple allegations on many occasions.

He is a hit man. He’s been brought in to take me down because they are very, very concerned about the adverse reactions to vaccines that are occurring in children.

COOPER: Wait a minute, sir. Let me just stop you right there.

(CROSSTALK)

COOPER: You say he’s a hit man and he’s been brought in by “they.” Who is “they”? Who is he a hit man for?

(CROSSTALK)

COOPER: This is an independent journalist who’s won many awards.

(CROSSTALK)

WAKEFIELD: Yes, he’s…

(LAUGHTER)

WAKEFIELD: And he’s — you know, who brought this man in? Who is paying this man? I don’t know. But I do know for sure that he’s not a journalist like you are.

(END VIDEO CLIP)

COOPER: Wakefield went on to claim later in the interview that you’re being paid by the Association of British Pharmaceutical Industries.

Are you?

(LAUGHTER)

DEER: No, I’m not. I have been paid by “The Sunday Times of London.”

COOPER: Have you ever been paid by — by — by them?

(CROSSTALK)

DEER: Never, never once. I can’t even remember the last time I ever spoke to them.

I think I did have a — I did have an interview with some people who did some work for them several years ago. That’s about the closest I have ever got to the pharmaceutical industry.

In fact, one of the awards I received, the citation was that I was probably the only journalist in Britain who investigates the drug industry. So, I don’t think that one goes very far.

COOPER: What initially sparked your interest in investigating Wakefield?

DEER: Well, it was just an absolute routine assignment.

There was a television program that had been paid for by American interest to be broadcast in the U.K., and I was just assigned to do a — do a piece on it. And it started out like that.

And we asked Dr. Wakefield for an interview. And, almost immediately, within a matter of hours, complaints were being made against me to my editors by Dr. Wakefield’s personal publicist.

COOPER: When was that that you started doing these investigations?

DEER: Oh, this was in October, November 2003…

COOPER: OK, because…

DEER: … a long time ago now.

COOPER: … as you know, James Murdoch, the owner of — of your employer, “The London Times,” joined the board of GlaxoSmithKline, which is a manufacturer of MMR. He joined that board in 2009.

DEER: Yes.

(CROSSTALK)

COOPER: Some people have brought that up as a — as a conflict of interest.

DEER: No, it’s absurd, absolutely absurd.

In fact, it’s interesting that, in the last 24 hours, the only American network to have shown no interest whatsoever in the “BMJ”‘s revelations has been the FOX network…

COOPER: I asked Wake…

DEER: The only — they’re the only people.

COOPER: I asked Wakefield to respond to your reporting that — that — that states that medical records of all of the 12 cases that he initially cited in his “Lancet” paper back in 1998, that — that none of them were accurate, fully accurate.

I want to you listen to what he said.

(BEGIN VIDEO CLIP)

WAKEFIELD: That is false. He has not interviewed the parents. That is absolutely not true.

(CROSSTALK)

COOPER: So, you’re saying the parents — no parents say that what — that what you have said about their children’s medical histories is false?

WAKEFIELD: No, they don’t. What I have said and what has been reported in that paper by me and my colleagues is exactly what we saw.

(CROSSTALK)

(END VIDEO CLIP)

COOPER: Did you speak to any of the parents from the 12 cases?

DEER: I personally interviewed one, two, three families of the 12. Somebody else — two others were interviewed on my behalf by other journalists. So, that’s five of the 12.

Oh, no, actually, I interview — and I have had conversations with another, so quite a substantial number…

(CROSSTALK)

COOPER: So, you’re basically saying he falsified or — or got wrong all of the medical history, one way or another?

DEER: I — I — I showed the “Lancet” paper that Wakefield published to a father of a child in California who is child number 11 of this series of 12, and he looked at the paper, and he just looked at what it said about his own child, and he said, “That’s not true.” And that was one of the parents of one of these children in the paper.

But I think Dr. Wakefield has a — has a solution here. These revelations have been published in the U.K. jurisdiction, which is the most onerous libel jurisdiction in the world. Dr. Wakefield should sue, because, if what Dr. Wakefield is saying is true, then he would have an easy case for libel against “The British Medical Journal,” against “The Sunday Times of London,” against me personally.

If what he is saying is true, then he must be the victim of the most sustained campaign of malicious libel that has ever been inflicted on any individual in history.

COOPER: And that’s what he’s saying he is.

(CROSSTALK)

DEER: Well, you know, he has a remedy, doesn’t he?

But the reason he doesn’t take this remedy — in fact, he tried to take this remedy once before, when the doctors’ Medical Protection Society was funding him to sue me, sue the television company, sue “The Sunday Times.” And what happened at the end? He discontinued his action, and he sent me a check. I actually received a check from his lawyers to pay my legal costs.

Dr. Wakefield has a remedy. The trouble is, he can’t take that remedy, because he’s a fraudster. And, after all these years, he’s finally been nailed. We have been able to, over the years, produce the evidence that he was being paid by lawyers. We were able to show that he received three-quarters-of-a-million U.S. dollars.

Next week, we’re going to itemize in “The BMJ” his business interests and the extraordinary sums of money he intended to make from his own vaccine, from diagnostic kits, and from all kinds of other weird products he was going to sell off the back of his scare.

Dr. Wakefield did this for the money. And, finally, he’s been nailed as a cheat and a fraudster, and not just in a sort of academic vanity sense, but in an area of where children’s lives have been put at risk, and, even more importantly, in a funny way, where parents of children with autism have been left to blame themselves, thinking it was their own fault for vaccinating their child that their child has gone on to develop autism.

These are forgotten victims of Dr. Wakefield, and these are people ultimately that Dr. Wakefield preys upon.

COOPER: You know, it’s interesting, because I have gotten a lot of e-mails from parents who don’t — who still believe in Wakefield or believe the research, and are angry at — at, you know, our reporting on this, angry, certainly, at your reporting on this. I’m sure you have heard from them many times over the years.

DEER: Oh, yes.

COOPER: And it is heartbreaking, because there is no answer for what is causing autism. And, clearly, there have been problems with vaccines in the past.

What do you — what do you tell parents? What do you say to them?

DEER: Well, I say to — I say to parents when I talk to them — and, you know, you discuss these things with them, and I will tell you, the killer question to ask these parents, if you get an even conversation with them, is to say, do you blame yourself?

And they do. And I have had parents absolutely break down in tears, blaming themselves, thinking it was their fault for vaccinating their child.

Now, what Dr. Wakefield is able to do is to take that energy of guilt and self-blame, which is quite understandable, but is quite wrong, take that, exploit it, turn it into money, turn it into a business. And that’s what he’s done. And he’s having a wonderful time in Jamaica. I saw you interviewed him in Jamaica. Very nice.

COOPER: Wakefield claims that — that his findings have been independently replicated. Is that true?

DEER: That’s completely false.

COOPER: I mean, he said they have been replicated in five countries around the world. That was news to me.

DEER: Completely false. That’s absolutely, completely false. What he does is what he’s been doing in front of these parents over many years. He takes tangential pieces of research that don’t really relate to what he’s saying and represent them as somehow endorsing what he said.

One of the papers in fact which he cites absolutely, explicitly denies that anything like what he suggests has been found.

COOPER: He — he also…

DEER: He just makes it up.

COOPER: He also claims that — that he wasn’t making a connection between vaccines and — and — and autism, that — that it was parents who — who started making that, that the purpose of the study wasn’t to look at possible associations between MMR vaccinations and autism, but that association came from parents.

DEER: No, he just makes it up.

Those parents were selected by him and the lawyer and the campaign groups — actually, a campaign group organized by a mother who doesn’t have a child with autism, does have a grievously disabled child who I saw in a CNN bulletin just 10 minutes ago.

These people together selected a group of parents who blamed MMR and brought them to the hospital for them to make that allegation. That’s one of the key ways in which this research was rigged. He knew who these parents were. He would telephone them at their homes, invite them to the hospital, bring them in and get them to make the allegations to other doctors.

COOPER: What has angered you most or surprised you most in the years now since 2003 that you have been looking into and investigating this?

DEER: What has angered or surprised me most?

I think what has angered me most is the — is the distraction away from the real needs of children with developmental disorders and the real needs of families who are looking after them, because, very often, the families of children, particularly the ones that Wakefield preys on, are people who are just desperate for answers.

Some of them are financially quite challenged as well. Many of them are — are — are terrified about what’s going to happen to their children in the future. And it’s really shocked me that somebody would really prey upon the vulnerable.

It’s almost as though, if you’re vulnerable, you get picked on. It’s almost as — it’s almost an animal thing that — that people prey on these — these really unfortunate families who have got a — who have got issues.

And I — I just think it’s a shame that the energy that has gone into this anti-vaccine campaign hasn’t gone into a campaign for better services for people with disabilities, more research to get to the bottom of these kind of problems. I think it’s a great tragedy, great diversion of resources.

COOPER: Brian Deer, I appreciate your reporting and I appreciate you talking about it. Thank you.

DEER: Thank you.

(END VIDEOTAPE)

COOPER: He said a great diversion of resources for a mysterious and terrifying threat and one that is growing.

I want to show you the numbers that explain the fear. According to the Centers for Disease Control, on average, an estimated one in 110 kids in the United States have an autism spectrum disorder. That’s just under 1 percent, according to the most recent data from 2006.

The number of cases has been growing since 2002. There’s no doubt about it. Now, the rate varies among states, and it’s important to point out that autism spectrum disorder includes a — a range of developmental disabilities,with the most severe being autism.

There have also been changes in how diagnoses are made. And that may explain some of the increase, but not all of it, according to experts. Something else you should know, boys are four to five times more likely than girls to develop an autism spectrum disorder.

And while there’s no known cause yet, clues are emerging. It’s estimated that about 10 percent of kids with autism spectrum disorders have a genetic and neurologic or metabolic disorder, such as fragile X or Down syndrome.

Autism spectrum disorder is obviously an incredibly heartbreaking diagnosis for parents. It’s also extremely costly for both the families and the health care system. According to a recent study, the estimated lifetime cost to care for someone with an autism spectrum disorder is $3.2 million.

Let us know what you think. Join the live chat right now at AC360.com.

We will continue to follow the controversy.

One problem I have seen with this media frenzy over the Wakefield fraud story is that they (the media) are falling into the old traps of false balance, faux controversy, and “he-said, she said” reporting. The question isn’t whether Mr. Wakefield is guilty of misconduct. The GMC has already ruled on that. Mr. Wakefield is not “the accused” but “the guilty”.

CNN has allowed people like Andrew Wakefield and JB Handley a platform to make mostly statements which, at the initial airing, are unchallenged, and unsupported accusations. These people have much experience with handling the media and have been able to avoid the topic of of Mr. Wakefield’s fraud and his proven ethical violations. I appreciate that Anderson Cooper has gone back to do some fact checking, but the damage is already done at that point.

Here is a segment where Anderson Cooper does some fact checking on Mr. Wakefield’s claims and accusations:

http://i.cdn.turner.com/cnn/.element/apps/cvp/3.0/swf/cnn_416x234_embed.swf?context=embed&videoId=health/2011/01/06/ac.kth.autism.debate.cnn

Anderson Cooper made an attempt to verify the claims Andrew Wakefield made. Andrew Wakefield claimed that regression followed shortly after MMR vaccination. This has never been replicated. The studies that Mr. Wakefield attempts to use as support do not support that claim. The one attempt to actually replicate the claim, the Hornig study, found there was no association between gastrointestinal symptoms, regression and the MMR.

Anderson Cooper says that the studies Mr. Wakefield cites are “beside the point”. He says that the studies found an association between GI complaints and autism…which isn’t really the case.

Mr. Wakefield and his supporters try to claim, repeatedly, that Mr. Wakefield did not suggest that MMR and autism are linked. Interestingly, his own publisher in a statement to Anderson Cooper says the opposite.

“Yesterday, ‘The British Medical Journal’ published an article deeming the research printed over a decade ago by Dr. Andrew Wakefield suggesting a connection between autism and vaccines fraudulent. Wakefield stands strong in asserting that the allegations of ‘BMJ’ journalist Brian Deer are entirely false.”

Here’s the transcript of that section:

We begin, though, as always, “Keeping Them Honest.”

Tonight, the emotional and bitter debate over childhood vaccines and autism is louder than ever, if that’s even possible. Tonight, supporters of Andrew Wakefield, a discredited doctor who’s now accused of outright fraud by “The British Medical Journal,” “BMJ,” are standing by their man. To them, he remains a hero and a victim.

Wakefield is the lead author of the 1998 study that triggered a worldwide scare over childhood vaccines. It suggested vaccines given to kids may cause autism. His study, which looked at just 12 children, has been discredited. And last year, “The Lancet,” the journal that originally published it back in 1998, they retracted the study over concerns about its methods and ethics, as well as financial conflicts of the interests — on interests on the part of Wakefield.

Months later, Wakefield actually lost his license. It was taken away, his medical license, in the U.K. And now an award-winning investigative journalist, Brian Deer, has uncovered evidence he says proves Wakefield deliberately faked his study. Deer lays out his case in a series of articles that began running last in the “BMJ” last night. In a moment, you are going to hear directly from Mr. Deer. He will respond to attacks that Andrew Wakefield made last night in an exclusive right here on 360.

Things got pretty heated. He denied point-blank every accusation laid out by Mr. Deer. Take a look.

(BEGIN VIDEO CLIP)

ANDREW WAKEFIELD, AUTHORED RETRACTED AUTISM STUDY: He is a hit man. He’s been brought in to take me down.

COOPER: Wait a minute, sir. Let me just stop you right there.

(CROSSTALK)

COOPER: You say he’s a hit man and he’s been brought in by “they.” Who is “they”? Who is he a hit man for?

WAKEFIELD: Who brought this man in? Who is paying this man? I don’t know.

COOPER: You’re basically saying this is a — some sort of conspiracy against you. Is that — is that your argument?

WAKEFIELD: Conspiracy is your word.

What this is, is a ruthless, pragmatic attempt to crush any investigation…

COOPER: Well…

WAKEFIELD: Because the truth is in that book.

(CROSSTALK)

COOPER: However, I have read Brian Deer’s report, which is incredibly extensive. Sir, I’m not here to let you pitch your book. I’m here to have you answer questions.

(CROSSTALK)

WAKEFIELD: If you read the record that I have set out in the book, you will see the truth. You will see a detailed…

(CROSSTALK)

COOPER: But, sir, if you’re lying, then your book is also a lie. If your study is a lie, your book is a lie.

WAKEFIELD: The book is not a lie.

I suggest you do your investigation properly before making such allegations.

(END VIDEO CLIP)

COOPER: Well, we believe in facts here at 360, so, today, we followed up on some of the claims that Mr. Wakefield made last night. If we got something wrong, we would want to set the record straight, obviously.

One point Wakefield was adamant about was that other researchers have reproduced his study’s findings.

(BEGIN VIDEO CLIP)

COOPER: You have been offered the chance to replicate your study, and you have never taken — taken anybody up on that. You have had plenty of opportunity to replicate your study.

(CROSSTALK)

WAKEFIELD: You just accused me of giving you a falsehood. I’m telling you that this work has been replicated in five countries around the world.

(CROSSTALK)

COOPER: Then why has it been completely discredited by — by — by public health officials around the world?

WAKEFIELD: I suggest you do your investigation properly before making such allegations.

OK, if you look up the name Gonzalez, if you look up the name Balzola and Krigsman, you will see that the work has been replicated independently by other doctors around the world. They fail to mention that in these allegations. And Deer has failed to mention that at any time. Is that honest?

(END VIDEO CLIP)

COOPER: Well, today, we tracked down three of those studies and spoke to experts about all five that Wakefield kept citing.

And what we found is, they’re basically beside the point. They looked at gastrointestinal problems in children with autism, and nothing else. Like Wakefield, they found an association between gastrointestinal problems and autism, but they say nothing at all about a connection between autism and vaccines. So his suggestion of any such link remains his alone.

Now, a lot of parents have stopped vaccinating their kids because of Mr. Wakefield’s study. There have been deadly outbreaks of infectious diseases like measles and whooping cough as a result.

I asked Wakefield about that.

(BEGIN VIDEO CLIP)

COOPER: Sir, what’s also growing in number is the number of children who have died because they haven’t been vaccinated. Do you feel any sense of responsibility for that?

WAKEFIELD: I have never said not vaccinate. I have offered, I have suggested that children have the option of single vaccines.

(END VIDEO CLIP)

COOPER: Now, what he means by that is giving kids separate vaccines for measles, mumps and rubella, rather than a three-in-one combination vaccine.

Parents in the U.S. can choose which type their kids get. We checked out the rest of his claim. And it’s true. We found no instance of him saying do not vaccinate, period.

In 2003, Wakefield told “The Sunday Herald” newspaper: “I think parents are well-informed. They are not inherently anti-vaccine, nor are we. We have advocated throughout that children continued to be protected, but, in the light of this evidence, there’s a question mark. And while that question mark exist, parents must have the choice over how they protect their children.”

That’s what he said. But, at the same time, Wakefield is the undisputed champion of the anti-vaccination movement. And the people in this movement commonly cite his research as the reason for not vaccinating their kids.

Wakefield has never stood up to put a stop to this movement. In fact, the forward of his book, the book he kept trying to promote last night, is written by Jenny McCarthy, a vocal autism activist who believes her son’s autism was caused by vaccines.

She writes: “Unfortunately, it appears that a product intended for good, vaccines, also has a dark side, which is the ability to do harm in certain children. This ability to do harm has unfortunately increased quite a bit in the last few decades because children today receive so many more shots than when — than when most parents were kids.”

McCarthy also writes that Andrew Wakefield — quote — “listened to parents who reported two things: Their children with autism were suffering from severe bowel pain, and the children regressed into autism after vaccination. He listened. He studied. And they published what he learned.”

So, even if Wakefield hasn’t said do not vaccinate in so many words, he has certainly fueled the fear and distrust of vaccines. Wakefield’s publisher released a statement today on his behalf, and its headline reads — quote — “Vaccines Continue to Ruin Some Children’s Lives While Mainstream Medical Community and Big Drug Companies Refuse to Respond to the Series Medical Concerns of Worried Parents.”

The release goes on to say: “Yesterday, ‘The British Medical Journal’ published an article deeming the research printed over a decade ago by Dr. Andrew Wakefield suggesting a connection between autism and vaccines fraudulent. Wakefield stands strong in asserting that the allegations of ‘BMJ’ journalist Brian Deer are entirely false.”

So, the release itself describes Wakefield’s research as — quote — “suggesting a connection between autism and vaccines.”

And that’s exactly why his study, which the “BMJ” now says is flat-out fraudulent, has become such a powerful piece of the autism- vaccine controversy.

Want to show you something else. This is from the study itself, the one that’s been debunked. It’s a table listing autism diagnoses in one column and then the vaccines the kids in the study received. The table also shows when the kids got the vaccines.

To an average parent, with no scientific background, that would look pretty scary, if it were true. You can see how many parents desperate for an answer might latch on to that data.

But, after seven years of investigating, Brian Deer says he’s proved the data was faked. Here’s what told me about when we talked earlier.

In the end, this is probably the last major spike of news attention for Andrew Wakefield. Sure, in his new role as spokesperson for a consortium of vaccines-cause-autism organizations, he will get in the news again. And there will be at least one more BMJ article. But, what else is there? His research efforts even before he was let go by Thoughtful House were unimpressive to say the least (remember the Monkey study that used 2 controls and claimed that unvaccinated infant monkey brians shouldn’t grow, but the vaccinated ones should?). Perhaps he will be a study author on the Generation Rescue “vaccinated/unvaccinated” study. Even that won’t gain him the notoriety of his Lancet paper. With the paper debunked, his ethical violations in pursuing that paper and others proven by the GMC hearing and, now, the entire effort described as fraudulent, what’s left? Not much.

You can’t question vaccines without being destroyed….or can you

7 Jan

As part of the “balance” in the Wakefield fraud story, CNN brought in Wendy Fournier of the National Autism Association. It’s a bit of an odd choice as she hadn’t researched the claims in the BMJ article (“honestly, I don’t know the specifics Brain Deer is referring to in the article for BMJ”). That said, the interview is interesting to watch. She starts right out with a personal attack on Mr. Deer: “Brian Deer has proven himself to be quite the one-trick pony. Wondering if has anything else to do than write about Andy Wakefield”.

The defense doesn’t talk at all about the actual paper, the actual demonstrated instances of fraud. Instead, the interview focuses on the conspiracy defense that Mr. Wakefield and his supporters have chosen. It isn’t that the data were manipulated to produce a given result that’s the reason why the editors at the BMJ produced this article, it is because the vaccine program is so important that vaccine safety advocates are attacked.

Here are two quotes from this interview:

“Careers are destroyed whenever anyone dares to question the almighty vaccine program” and “you can’t question vaccines without being destroyed, there’s too much money at stake here”

http://i.cdn.turner.com/cnn/.element/apps/cvp/3.0/swf/cnn_416x234_embed.swf?context=embed&videoId=health/2011/01/06/intv.austism.study.defended.cnn

Consider the case of John Salamone. Have you ever heard of him? I hadn’t until I read Dr. Offit’s book, Deadly Choices. Mr. Salamone has a vaccine injured child. His son contracted polio from the oral polio vaccine. Mr. Salomone found out that there was a safer vaccine, the Salk vaccine, which was already in use in other countries. Mr. Salamone formed a group, informed parents against vaccine associated polio, and took his case to the government. It wasn’t an easy battle, by far. But he did eventually get heard and he made the change happen. The U.S. abandoned the oral vaccine.

He wasn’t ruined. There was no campaign to destroy him.

He was the right man, with the right skills to get the job done. He also had the truth on his side and he didn’t resort to fear and pseudo science.

Here is a quote from a parent “autism advocate” in one of the groups associated with the NAA, Generation Rescue. This statement was written on the blog these groups share, the Age of Autism. I don’t recall anyone from the NAA voicing an objection to this comment when it was made:

With less than a half-dozen full time activists, annual budgets of six figures or less, and umpteen thousand courageous, undaunted, and selfless volunteer parents, our community, held together with duct tape and bailing wire, is in the early to middle stages of bringing the U.S. vaccine program to its knees

When people assert that the vaccine program is untouchable, that anyone who questions it will be “destroyed”, think about the changes that have already occurred. Think about John Salamone. Thank him for bringing about the change he did.

Journalist: US Should Probe Wakefield

6 Jan

Brian Deer, the investigative journalist who first broke the story about the fraudulent research activities of Andrew Wakefield, was interviewed by CNN UK.

I am glad that CNN gave Mr. Deer the chance to take on the claim that Mr. Wakefield’s research has been replicated. It hasn’t (see our discussion here). Mr. Deer states that criminal charges should be brought against Mr. Wakefield and that his immigration status should be checked.

http://i.cdn.turner.com/cnn/.element/apps/cvp/3.0/swf/cnn_416x234_embed.swf?context=embed&videoId=health/2011/01/06/autism.fraud.probe.deer.cnn

I’ll get the transcript up as soon as I can find it.

JB Handley of Generation Rescue on CNN

6 Jan

First of all, here’s the transcript of Handley on CNN, courtesy of Liz Ditz:

Parker: Now joining us from Portland, Oregon I J.B. Handley. JB is the father of an eight-year old with autism, and he is a founder of Generation Rescue, a group that believes that there is a connection between autism and vaccination. Welcome JB

JB Handley (JBH): Thanks for having me.

Parker: Thank you Did today’s report cause you to reconsider your position on vaccines at all?

JBH: No, not one bit.

Parker: So, explain that. Why doesn’t this affect the way you think?

JBH: You know the original Wakefield study looked at 12 children. All 12 had autism. The only conclusion of the study was that the 12 were suffering from a new form of bowel disease. Andy Wakefield also reported that 8 of the parents said that their children regressed after the MMR vaccine. So the notion that his study ever incriminated MMR as causing autism is false. and the vaccine industry continues to beat this dead horse.

Parker: so you think that um when you talk about regression you are saying not so much that uhm the vaccine causes autism but that it causes a regression? And what does that mean to you?

JBH: No. What you hear from many parents, and my son is one of these, is that the children are developing typically, and my son’s case up to 14 months he was normal, and then then they gave a regression, they start to lose skills, they start to lose milestones. I have personally talked to about a thousand parents who all report that their children where that regression took place immediately following a vaccine appointment.

It’s important for parents to understand that children are given 36 vaccines in the US by the time they are the age five. The MMR only accounts for two of those 36 vaccines. Typically the shots are given simultaneously so the average child will get six vaccines in a single appointment, yet we don’t have a single piece of research to understand the potential risk of all those vaccines at once. So when someone tries to tell me that MMR alone doesn’t cause autism, but I take my child in for a vaccine appointment, and they are getting six shots in 10 minutes, how am I supposed to feel reassured?

Spitzer: I say this with overwhelming sympathy for you and for your son, but just listening to you I’ve got to ask the question: there isn’t a single study, and we’ve looked at all the science, that says there’s any causal link between these vaccines and autism. And I know you are saying there is

JBH: But that’s not true

Spitzer: there isn’t a study that disproves it, but there’s no affirmative causal link there. And so don’t don’t you think it would make more sense to look at other potential potential causative factors?

JBH: What you are saying is simply false. There is a study out of SUNY Stonybrook within the last six months that compared a group of children who got the entire round of HepB vaccine, and a group of children who didn’t, and found autism was three times more likely in one group. There’s a new study out of the University of Pittsburgh that took primates and vaccinated a group of them and didn’t vaccinate the another and found dramatic differences between the two sides. So to represent that somehow the science has been done is simply false. More importantly the science that has been done is what we like to call “tobacco science”. You take a group of kids who all got vaccines but got a little less mercury and compare them to a group of kids who all got vaccines but a little more mercury and find there’s no difference in autism and then claim that vaccines don’t cause autism. The only appropriate study to do would be to look at a group of children who never got vaccines and a group of children who got all of them, and see if there’s a difference in autism rates and that study has never been done despite many people trying to call for it.

So to represent that the science has been done on this is simply untrue. The vaccine makers are highly effective at PR and which is why I am here talking to you.

Parker: Well JB you obviously feel passionately about this and we can certainly understand that. How do you feel specifically about, when you find out that this particular doctor was when Wakefield was actually deliberately fraudulent in advancing the claim that there was a connection?

JBH: What is interesting is that there are 12 children in the original study in the Lancet, OK? The parents of the 12 children have all written letters, time and again, in support of Andy Wakefield. The study’s conclusion was that the children were all suffering from bowel disease, and Andy went on to mention eight of the parents claimed that the regression took place after the MMR. So the notion that the data is somehow new, what’s new? They didn’t suffer from bowel disease, even though all the parents have represented that they did? People need to look at the details not at the headlines. This an attempt to whitewash, once and for all, the notion that vaccines cause autism. They are not just beating a dead horse, they are beating a horse that never existed in the first place. That’s not what Wakefield’s study said. It’s a seven page page study, it is on the Generation Rescue website. Anybody can read it for themselves and verify what I am saying is true.

Spitzer: JB, again with all sympathy, and as somebody who has been a harsh critic of

JBH: I don’t need any sympathy!

Spitzer: Well, OK but what I am trying to say is

JBH: [talking over] I don’t need any sympathy! I don’t need your sympathy What I need is the facts and for someone to look at the details.

Spitzer: Well what you yourself have said is that what you glean from your anecdotal conversations is hugely compelling to you but unfortunately in terms of the scientific data and the analysis that sort of anecdotal database simply doesn’t establish the causal link what we are looking for in terms of really understanding this and I think that what validates today

JBH: [talking over] Look at the Suny Stonybrook study, look at the university of Pittsburg study

Spitzer: [continuing over JB] this study that we examined today was fraudulent. And I think that’s really where we are.

JBH: [talking over] Look at the Suny Stonybrook study, look at the university of Pittsburg study. You haven’t done all your research. You are reaching false conclusions. Parents do your own work.

[pleasantries to close]

Now lets isolate Handley’s main talking points and decide if they are true or false:

1) You know the original Wakefield study looked at 12 children. All 12 had autism.
Not accurate. According to material from the British Medical Journal three of nine children reported with regressive autism did not have autism diagnosed at all. Only one child clearly had regressive autism.

2) Andy Wakefield also reported that 8 of the parents said that their children regressed after the MMR vaccine.
Not accurate. According to the same source five had documented pre-existing developmental concerns.

3) So the notion that his study ever incriminated MMR as causing autism is false.
Semi-accurate. Although the paper itself may not have mentioned it, the video conference Wakefield gave _about_ the study certainly did:

…you would not get consensus from all members of the group on this, but that is my feeling, that the, the risk of this particular syndrome developing is related to the combined vaccine, the MMR…

4) …we don’t have a single piece of research to understand the potential risk of all those vaccines at once.
Not accurate. Any vaccine in the US has to undergo something called a ‘concomitant use study’. These are to establish that vaccines work OK together. Searching Pubmed for the phrase ‘concomitant vaccine’ returns over 700 results.

5) There is a study out of SUNY Stonybrook within the last six months that compared a group of children who got the entire round of HepB vaccine, and a group of children who didn’t, and found autism was three times more likely in one group
Not accurate. This study is flawed on an number of levels. Firstly, they are comparing kids born as early as 1980 to kids born during “the epidemic”. Anything that happened past 1991 would be an autism risk. Secondly and very worryingly, they pick datasets that have children born before the introduction of the Hep B vaccine. Thirdly, this whole thing is essentially a survey. It’s based on parental recall.

6) There’s a new study out of the University of Pittsburgh that took primates and vaccinated a group of them and didn’t vaccinate the another and found dramatic differences between the two sides.
Not accurate. Again, lots of issues with this study. So many so in fact that Sullivan wrote a devastating takedown of the paper in July last year.

I think that’s all the statements of attempted fact from Handley. All in all it shows that Generation Rescue cannot be trusted to present the most pertinent or up to date information.

Brian Deer on CNN, responds to Andrew Wakefield’s wild charges

6 Jan

Brian Deer is the investigative reporter who broke the story of the research fraud that Andrew Wakefield conducted in his autism/MMR studies. Andrew Wakefield made some serious charges against Mr. Deer yesterday, claiming ” He is a hit man. He’s been brought in to take me down because they are very, very concerned about the adverse reactions to vaccines that are occurring to children. Who brought this man in, who is paying this man, I don’t know.”

Mr. Deer was interviewed on CNN today. Here is that segment:

http://i.cdn.turner.com/cnn/.element/apps/cvp/3.0/swf/cnn_416x234_embed.swf?context=embed&videoId=bestoftv/2011/01/06/am.chetry.deer.autism.cnn

here is the transcript

CHETRY: Yes. And so, this is certainly a bombshell of a story this morning. The study that linked the MMR vaccine to autism caused shock waves when he it was published back in 1988 in the medical journal “Lancet.” But by 2004, most of the paper’s co-authors had withdrawn their support. Then last February, “Lancet” retracted that report saying the research was, quote, “unethical.” Last summer, Dr. Wakefield was then barred from practicing medicine in Britain.

And Brian Deer is the investigative journalist who really blew the lid off of this story. And he joins us live from London this morning.

Brian, good morning.

BRIAN DEER, INVESTIGATIVE JOURNALIST, SUNDAY TIMES OF LONDON: Good morning.

CHETRY: One of the things I want to ask is: what is the — what was the most motivation then for Dr. Wakefield to falsely link autism to the MMR vaccine in that initial study?

DEER: Well, I believe that his motivation was essentially to make money. Initially to make money from litigation, he was retained as an expert in a lawsuit for which we know he was paid three quarters of a million U.S. dollars. But he also had all kinds of business interests which he thought would make considerably more money through promoting the scare and promoting public anxiety through over the MMR vaccine.

CHETRY: And then the question seems to be: why would there be all of these other co-authors? And why would it make its way into a prestigious journal like “Lancet” and really shape the discussion and the fears about autism linked to vaccine?

DEER: Well, that’s one of the great weaknesses of medicine and medical publishing, is that people can publish things that are false. People talk about peer review and such like. And they imagine they’re some kind of safety system. But, in fact, the whole system works on trust. His co-authors didn’t know which child was which in the study that he published.

And so, it is actually possible for determined cheat to get away with the kind of behavior that Dr. Wakefield has been involved in.

CHETRY: Well, Dr. Wakefield is still continuing to stand by his study and his findings. Anderson Cooper actually talked to him last night. He went after you. He accused you of being part of a conspiracy to discredit him.

Let’s just listen to a bit of what he said. Also, he claimed that you were getting paid to do this — to do this investigation. Let’s listen.

(BEGIN VIDEO CLIP, CNN’S ANDERSON COOPER 360) DR. ANDREW WAKEFIELD, ACCUSED OF FAKING AUTISM RESEARCH: I have read his multiple allegations on many occasions. He is a hit man. He’s been brought in to take me down because they are very, very concerned about the adverse reactions to vaccines that are occurring to children. Who brought this man in, who is paying this man, I don’t know.

(END VIDEO CLIP)

CHETRY: Did you have a financial interest in doing this investigation, Brian?

DEER: I’ve been an investigative journalist working for “The Sunday Times of London” since the early 1980s.

The point you have to remember about this whole issue is, firstly, that it’s not me saying this. It’s the editors of the “BMJ,” a very prestigious medical journal who peer reviewed and checked of the facts which we put forward in our investigation this week. So, it’s not me saying it. It’s the editors of that journal who are behind this.

But secondly, this material has been published in the United Kingdom in extraordinary detail. If it is true that Andrew Wakefield is not guilty as charged, he has the remedy of bringing a liable action against myself, against “The Sunday Times of London,” against the “British Medical Journal,” against television networks here — and he would be the richest man in America.

(CROSSTALK)

CHETRY: But he’s alleging that you were being paid to do this article. I mean, you were paid, right, because you were a journalist?

DEER: I was commissioned by the “British Medical Journal” to write the piece, yes. That’s what the journalists do.

CHETRY: What about “The Sunday Times of London” and Channel 4 in Britain?

DEER: I work for them. Right. Yes, of course, they pay, I’m a journalist. I was hired to do a job, like you are.

CHETRY: Right.

DEER: You are being paid to your job and I’m being paid to do my job.

CHETRY: Thank goodness.

The bottom line, though, is he’s questioning your motivations for going after him? Clearly, what are your motivations for going after Dr. Wakefield and his study?

DEER: It was simply a journalist assignment given to me late in 2003. A simple journalistic assignment which I expected would last a week or two weeks. And it just completely opened up when Dr. Wakefield began what we know has established a campaign of lies. When you’re a journalist and you see somebody you’re dealing is lying to you, then you pursue it. He then sued me. He was then required to may my costs. So, I received a check on his behalf, the previous false lawsuit that he began.

And now, what he’s trying to do, cloud the picture by — in the same way as he used to cloud the picture by saying some doctors say the vaccine is safe. Some doctors say it isn’t safe.

Now, what he’s trying to do is to say, well, some people say that he’s a liar and he says that I’m a liar.

CHETRY: Right.

DEER: So, what he’s trying to basically do is to split the difference. On that basis, he can work a nice living which he’s got going. You should see him in Jamaica this weekend, which he’s having a marvelous sometime on the expense of parents of autistic children.

CHETRY: Well, I want to ask you about that. What has been the impact of this safety on calling into question the safety worldwide of certain vaccines?

DEER: Oh, it’s been absolutely devastating because he and a little clique of lawyers and activists around, anti-vaccine activists around him, have been able to spread anxiety, to export it from the United Kingdom, bring it across the Atlantic, the United States, with the result, we’re now seeing parents anxious about vaccination. We’ve seen just the worst outbreak of whooping cough in California since the 1950s.

CHETRY: Are we going to understand autism and what causes it, though? Because we have seen this rise, 50 percent from 2002 to 2006 in children identified with autism spectrum disorder? I mean, why is it increasing like this?

DEER: Well, I’m a journalist, I’m not a doctor. And I don’t give medical advice. I can say from what I understand talking to doctors and scientists is that the (INAUDIBLE) conditions which cause autism, autisms, neurological problems in children, are very complex issues. And science just doesn’t have the answer.

So when someone like Dr. Wakefield comes along that gives a simple answer that blames other people, blames drug companies, now blames me, it’s all my fault, a very small number of parents become misled by that and cling to this. Because their choice is basically blame somebody else or suffer the possibility that they’re left with the guilt of thinking it was their fault that they vaccinated their child. So, it’s a very vulnerable group that Dr. Wakefield preys on.

CHETRY: Well, your reporting certainly is getting attention this morning. All of it is going to be out there along with the editorial as well. We look forward to seeing all of this.

Brian Deer, thanks for joining us this morning.

DEER: Thank you.

Seth Mnookin responds to Andrew Wakefield on CNN

6 Jan

Seth Mnookin is the author of the upcoming (next week) book “The Panic Virus“. As someone who spent 2 years researching the issue of the vaccine/autism hypothesis, he was chosen to respond to Andrew Wakefield on CNN.

They note this in the story, but I will point it out again here: Andrew Wakefield would not appear together with Mr. Mnookin. This isn’t new. Last year the program “The Doctors” had a program with Jenny McCarthy, J.B. Handley, Dr. Jerry Kartzinel and others–where they only agreed to go on air if the there were no people with opposing views present.

http://i.cdn.turner.com/cnn/.element/apps/cvp/3.0/swf/cnn_416x234_embed.swf?context=embed&videoId=health/2011/01/06/ac.discussing.wakefield.cnn

Mr. Mnookin points out that Mr. Wakefield tried to frame the story as a single reporter (Brian Deer) “out to get him”.

He has framed this consistently as this one renegade journalist who’s out to get him. In fact, there was a British — the Medical Research Council, which licenses doctors in the U.K., spent two-and-a- half years looking into his work. It was the longest investigation they had ever done.

On the subject of Mr. Wakefield’s scientific credibility:

GUPTA: No, I think that — I think this is a pretty big deal, what’s happened today.

But, you know, he didn’t — he hasn’t had really credibility within the scientific world for some time. I mean, as you pointed out, he’s been stripped of his medical license. The paper has been retracted. His co-authors all essentially left the paper.

The problem is that Mr. Wakefield’s audience is not the scientific community. The damage he does is not within or to the science community. The damage is to public health and to the autism communities. I am hopeful that this paper in the BMJ will reduce what credibility Mr. Wakefield still has and the damage he is causing.

Mr. Mnookin has a blog post of his own on the BMJ article and editorial: The problems with the BMJ’s Wakefield-fraud story

Here is the transcript:

COOPER: Also joining us right now is Seth Mnookin, author of “Panic Virus.”

Andrew Wakefield would not go on the program with you.

SETH MNOOKIN, AUTHOR, “THE PANIC VIRUS: A TRUE STORY OF MEDICINE, SCIENCE, AND FEAR”: Right.

COOPER: He would only go on if Sanjay and I were — were asking the questions.

What do you make of what he said?

MNOOKIN: I find it — I find it upsetting and — and disturbing.

He has framed this consistently as this one renegade journalist who’s out to get him. In fact, there was a British — the Medical Research Council, which licenses doctors in the U.K., spent two-and-a- half years looking into his work. It was the longest investigation they had ever done.

And that was the group that stripped him of his right to practice medicine and — and said that he had displayed a callous disregard for children.

There have been dozens of studies.

COOPER: They said a callous disregard for children?

MNOOKIN: Callous disregard for children.

COOPER: That’s why — and that’s — in stripping him of his — of his license?

MNOOKIN: Well, the — the — there were several reasons they listed. The callous disregard had to do with performing unnecessary tests on children who had been brought to him to support this point, including spinal taps, invasive examinations, colonoscopies on very, very young children.

They also found that there was — his evidence couldn’t be backed up. His — his data couldn’t be backed up. So, for it to be portrayed by — by — by Andy Wakefield as this being one person out to get him, you know, I think what he’s banking on is that people won’t actually look and see — look and see what the reality of the situation is.

(CROSSTALK)

COOPER: When you read this report by — by Deer…

MNOOKIN: Right.

COOPER: And I don’t know this guy Deer at all, but, I mean, I have read his entire report. It’s — it’s — it’s pretty exhaustive.

MNOOKIN: Not only is it exhaustive, but, if you took out everything that Brian Deer had ever written, there would be exhaustive evidence that — that this was not trustworthy.

Dozens of researchers in dozens of countries have studied literally millions of children around the world. And this notion that there’s some sort of conspiracy between public health officials, doctors, journalists, drug companies, researchers around the world, you know, it — it would be the most brilliant conspiracy that had ever been hatched.

And — and — and Andrew Wakefield’s setting himself up as this one renegade or this band of renegades, you know, sort of fighting against this is — is, I think, laughable.

COOPER: Sanjay, does he have any credibility?

GUPTA: No, I think that — I think this is a pretty big deal, what’s happened today.

But, you know, he didn’t — he hasn’t had really credibility within the scientific world for some time. I mean, as you pointed out, he’s been stripped of his medical license. The paper has been retracted. His co-authors all essentially left the paper.

COOPER: But, you know, let me just say one thing. Because there — there is so much distrust of big pharmaceutical companies, there are going to be a lot of people watching this who say…

GUPTA: Well, that…

COOPER: … you know, we’re all in the pockets of big pharma, or, you know, that — that there is this conspiracy.

GUPTA: That’s what I was going to say. I don’t know that it’s going to change people who are still going to be very concerned about vaccines.

And the reality is that, if we had a great answer as to what causes autism, I think that would — that would change this debate altogether. But we don’t. So, you — it’s trying to prove a negative, obviously, an impossible thing to do.

But, in his case, I — I don’t think that it — while as big a deal as this is in science today, I don’t know how much this changes the debate overall, because his — his — his science has been discredited in the scientific community for some time.

COOPER: But — but, I mean, it’s understandable. Look, parents — look, we don’t know about — a lot about autism, and — and the numbers are growing. And that is — is of concern. And it’s understandable parents would latch on to anything.

But — but in terms of just facts, and we do — you know, I believe in facts a lot on this program — I mean, Seth, are there peer-reviewed scientific reports that — that indicate a link between…

MNOOKIN: No.

COOPER: … between vaccines and — and autism?

MNOOKIN: No. And not only is there not peer-reviewed work, this is probably the most studied public health issue involving children over the last 20 years.

COOPER: Would public health officials have an interest in — in hiding a link, if there was?

MNOOKIN: Public health officials, I think, would have an interest in keeping children safe.

Even if there — if there was a link and it was discovered, I think public health officials would — would have an interest in doing whatever they could to protect children. This notion that everyone’s trying to — to — to cover their butts and — because they have already been — been perpetrating this scam, is — to distrust the motives of that many people around the world, you know, you would need to assume that — that everything going on is in some ways out to get you.

I think Sanjay’s point about our not knowing what causes autism is really in some ways the crucial one, because it’s so frightening to parents. The numbers are rising. And here’s something that you can point to. And because it occurs at the same time, you always get vaccinated when you’re a child, and autism is diagnosed when you’re a child, so it’s easy to understand why patients would latch on to that as a connection.

But it has no more validity than — than if I said microwave popcorn causes autism. The numbers have gone up since we have started eating microwave popcorn. There’s just — there’s absolutely no evidence supporting a link.

COOPER: Do — do you agree with that?

GUPTA: Yes. I mean, and I think…

(CROSSTALK)

COOPER: And, as a parent, what do you tell other parents?

GUPTA: Well, I — I have three children. I got my kids vaccinated on schedule, on time. So, you know, I mean, that’s — I think the proof’s in the pudding in my case, because I had to make that decision.

But I think, also, you know, that I — you could get a sense of where the debate goes from here. Wakefield’s paper may be discredited, but we still don’t know. We give more vaccines now. We give them in different schedules. Could there be something new that’s possibly causing this uptick in autism?

And — and — and I think the question is going to remain out there, despite what’s happened today. You know, the smallpox vaccine, when it was given, it causes an immune response to the body. It was a — a really profound immune response, more powerful than all the vaccines that we give today, and yet the autism rates are higher now.

So, if it’s the vaccine itself, why wasn’t it happening when we gave these really, really powerful vaccines so many years ago?

COOPER: And, Seth, the report that is out today by this journalist Deer, it indicates that he had a financial — that Wakefield had a financial motive.

MNOOKIN: Right.

COOPER: What was the financial motive?

(CROSSTALK)

MNOOKIN: Well, there were a couple of things.

One, he had filed a patent application for an alternate measles vaccine several months before the paper came out, which he did not disclose at the time. It was precisely the vaccine that you would have wanted if you stopped using the three-in-one MMR vaccine. It was just for measles.

So, that’s one very obvious thing. He also was — his work was being funded by a law firm that was involved in potential vaccine litigation. And a number of the children in this study were also involved with that law firm.

So, the — for — for him to say, you know, “I had no financial connection, and, to prove it, you should read my book,” you know, it — it’s — it’s sort of like saying, no, no, I swear I’m a good guy, and, to prove it, listen to me.

It — you know, it just doesn’t hold up.

COOPER: I read — I read in “Newsweek” this week in an article you wrote about kids who have died because they haven’t been vaccinated…

MNOOKIN: Yes.

COOPER: … died — died from things that they shouldn’t have died of. MNOOKIN: Yes.

COOPER: Whooping cough.

MNOOKIN: In 2010 alone, 10 infants died of whooping cough in California, which is astounding that that is happening today.

There are children that have died of Hib, diseases that I have always assumed were definitely in the past in this country. There was a measles epidemic several years ago in California, in San Diego, that cost $10 million to contain, and resulted in a quarantine of dozens of children.

That meant that those parents then had to find some way to take care of those kids, either not go to work or pay for day care. So, even when you have a case like with that measles epidemic, where it’s true that children didn’t die, you had one infant that was hospitalized for a serious amount of time, and dozens of families that had to pay an enormous amount of money because of this.

COOPER: This is maybe an unfair and an impossible question to answer, is, do you believe Wakefield believes what he’s saying?

MNOOKIN: I talked to him several times over the past several years. Mostly in the context of these conferences that he was referring to where he’s surrounded by people who adulate him.

I think that it’s certainly possible that, at this point, he’s been living in this for so long that he thinks it’s true. I have talked to other people involved in that community who have told me candidly that they wish the conversation could move on from that, because they understood that the science is not…

COOPER: Has the media played a role in perpetuating this? Because you see in a lot of TV shows, you know, on this subject, several sides represented. You have the people who believe the vaccines cause autism and the people who don’t. And it seems to give equal credence, you know.

Or you have a famous person, you know, like Jenny McCarthy, and nothing against her personally, but you know, who is going to get a lot of attention. Has that made the problem worse? Has that given the — this side more credence?

MNOOKIN: I think absolutely. And an example I use is there are people who believe the earth is flat. Most people obviously do not, but if you had one person who believed the earth is flat and one person who said, “No, it’s actually round,” and they were discussing the issue together, it would seem that the consensus was split 50/50.

So here you have a situation in which you have millions of doctors, public health officials, all coming down on one side, and then Andrew Wakefield and a very small number of people who are associated with him, a miniscule number of people, saying, “No, this is what’s actually going on.” But because we can’t present millions of points of view or millions of people, it ends up sounding — there’s this false equivalency. It ends up sounding on the one hand, on the other hand, when there really is only one hand in this case.

COOPER: Do you agree with that, there is only one hand in this?

GUPTA: Yes, and I mean, the one thing I would say with the earth, flat earth, round thing, is we know the answer to that now.

One of the things that again has made this discussion so difficult is that, at the end of the discussion, no matter how much you disagree with the other person, if they come back to you and say, “So what does cause it?” We still don’t have that great answer. It could be some environmental unknown with a genetic predisposition. Who knows? But that, in part, has made this difficult.

Also, you know, just as a parent, I can tell you, it’s so deeply personal. And that also, despite what’s happened today, I think many parents who are dealing with this right now are still believing this, despite all the evidence to the contrary.

COOPER: It’s a fascinating topic. I appreciate both you guys being here with your expertise. Thank you. Dr. Sanjay Gupta, Seth Mnookin.

Andrew Wakefield on CNN

6 Jan

http://i.cdn.turner.com/cnn/.element/apps/cvp/3.0/swf/cnn_416x234_embed.swf?context=embed&videoId=health/2011/01/05/ac.autism.wakefield.intv.cnn

Best bit? The journalist telling Wakefield to shut up about his book.

The National Autism Association tries and fails to defend Andrew Wakefield’s fraud

6 Jan

Of the groups pushing the vaccines-caused-an-epidemic-of-autism idea, the National Autism Association stands out. In a good way. They are the one group that actually has a non-vaccine segment to their agenda. They presented recently at the IACC on issues of safety. Unfortunately, they are stuck in the vaccine-causation debates of 10 years ago. Case in point: coincident with the lifting of the embargo on the BMJ’s pieces on Andrew Wakefield (e.g. How the case against the MMR vaccine was fixed) the NAA put out a statement defending Mr. Wakefield. (National Autism Association Says BMJ Article is Yet Another Attempt to Thwart Vaccine Safety Research)

As a part of this defense, they claim that Mr. Wakefield’s research has been replicated. The claim has been made before and upon scrutiny shown to be false. They use 5 references:

(1) Clinical Presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic Spectrum Disorder and Chronic Gastrointestinal Symptoms, Arthur Krigsman, MD, et al, New York University School of Medicine, Autism Insights, 27 Jan 2010

(2) Endoscopic and Histological Characteristics of the Digestive Mucosa in Autistic Children with gastro-Intestinal Symptoms. Gonzalez L, et al. ArchVenez Pueric Pediatr, 2005;69:19-25.

(3) Panenteric IBD-like disease in a patient with regressive autism shown for the first time by wireless capsulenteroscopy: Another piece in the jig-saw of the gut-brain syndrome? Balzola F, et al. American Journal of Gastroenterology. 2005. 100(4):979-981.

(4) Childhood autism and eosinophilic colitis. Chen B, Girgis S, El-Matary W.. Digestion. 2010;81:127-9. Epub 2010 Jan 9].

(5) Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report, Timothy Buie, MD, et al, Department of Pediatrics, Harvard Medical School Pediatrics, Vol. 125 Supplement January 2010

Taking a lead from Catherina at JustTheVax, who showed last year that the “replication” of Mr. Wakefield’s results was not independent nor a replication, I will take a look at the 4 papers which are purported to “confirm” and association between autism and bowel disease.

1) A paper by Arthur Krigsman in Autism Insights. Arthur Krigsman was one of Andrew Wakefield’s partners at Thoughtful House when he wrote this. Both have since left. Autism Insights is an online journal whose editors include Dr. Krigsman himself. At the time Dr. Krigsman’s paper was published, the editorial board also included Andrew Wakefield. (strangely, Mr. Wakefield is no longer listed on the editorial board). Hardly independent. Right now, Autism Insights has 18 editors. They also have 8 published papers. Yes, they have twice the number of editors as papers. One has to question if this is a real journal. The Krigsman paper was timed to come out to support Andrew Wakefield at a time when his press was quite poor. Not a replication.

2) Gonzalez, et al.. From JustTheVax:

Gonzales et al, number 2, has been published in “Arch Venez Pueric Pediatr” which stands for Archivos Venezolanos de Puericultura y Pediatría. It was a bit tricky to get my hands on the paper, especially since the citation was not quite right, but I did manage and was not surprised to find that indeed the authors cannot replicate Wakefield’s 1998 “findings” of a distinct autistic enterocolitis, although they do report a higher incidence of gastrointestinal problems in their autistic group.

3) Balzola, et al.. Again, from Catherina:

Balzola et al, number 3, is a case report of one adult autistic patient with inflammed bowel.

4) Chen, et al.. Here’s the abstract, which spells out a rare association in 2 children, with possible mechanisms that may connect the two.

BACKGROUND/AIMS: The significance of the association between many gastrointestinal pathologies and autism is yet to be discovered. The aim of this report is to highlight an association between autism and microscopic eosinophilic colitis in 2 children. The possible mechanisms that may connect these two conditions are discussed.

METHODS AND RESULTS: A rare association between autism and microscopic eosinophilic colitis in 2 children is reported through retrospective chart review. Common causes of secondary eosinophilic colitis were excluded.

CONCLUSION: This report suggests the possibility of either impaired intestinal barrier function or an aberrant immune system that predisposes autistic children to sensitization to environmental antigens. Large controlled studies are needed to examine this hypothesis.

5) Bui, et al.. Here is the paragraph in that paper discussing Mr. Wakefield’s work:

In 1998, Wakefield et al. reported an association between ileocolitis and developmental regression in 12 children and coined the term “autistic enterocolitis.” From the same uncontrolled study they reported NLH of the ileum and colon as an abnormal finding in most children with ASDs. However, similar findings are known to be present in children with typical development, as well as children with food allergies and immunodeficiencies. The significance of these findings, therefore, is unclear. Wakefield et al. also proposed a causal relation between measles, mumps, and rubella (MMR) vaccination and autism, a suggestion that was later retracted by many of the original authors.

None of these papers is a replication of Mr. Wakefield’s work. And this is the best that the NAA can do to support Mr. Wakefield’s work, given 12 years of research since his paper in the Lancet. It also avoids the very clear problem with trying to “replicate” or “confirm” work that was fraudulent to begin with.

What is even more strange is that the NAA goes on in their piece to discuss the hypothesized link between autism and vaccines. Strange because Mr. Wakefield has been strenuously distancing himself from the impression that his paper “proved” a link between autism and vaccines.

Mr. Wakefield’s work was fraudulent. The BMJ says so in clearly and conclusively. It is time for some autism parent organizations to distance themselves from this man and his work. They are doing themselves and the autism communities as a whole any good by further association with him.

Current Trends In Autism Conference – April 29-30, 2011

6 Jan

I’ve written before here at LeftBrainRightBrain about the upcoming Current Trends in Autism Conference. At the time I first heard about it, I was hopefully optimistic that a good conference might be in the works. Autism parents are in great need of a real science based conference. The conference is being organized by the Lurie Family Autism Center LADDERS (“Learning and Developmental Disabilities Evaluation & Rehabilitation Services”).

The speaker list is now available, and I copy it below (go to their site if you want live links for each speaker):

Current List of Speakers
Margaret L. Bauman, MD
Director, TARF and LFAC/LADDERS/MGH; Associate Professor of Neurology, Harvard Medical School

Timothy Buie, MD
Pediatric Gastroenterologist, LFAC/LADDERS/MGH

Katarzyna Chawarska, PhD
Director, Toddler Developmental Disabilities Clinic, Yale School of Medicine

Ann Densmore, EdD CCC SLP/A
Founder, Child Talk; Author

Marie Duggan
Founder/President, Technology For Autism Now; AAC/AT Consultant, Boston Higashi School for Autism

Peter Gerhardt, EdD
Founding Chair, Scientific Council, OAR; Director of Education, Upper School, The McCarton School

Charles Henry, MD
Child Psychiatrist, LFAC/LADDERS/MGH

Dorothea Iannuzzi, LICSW, BCBA
Individual and Family Clinician, Milestones, Inc.

Michael A. Mancusi, LICSW, BCD
Vice President, Health Center Operations, East Boston Neighborhood Health Center

Marvin Natowicz, MD, PhD
The Cleveland Clinic, Autism and Metabolic Disorders

Jerry Newport
Autism Activist; International Speaker; Subject of the Feature Film Mozart and the Whale; Author

Carlos Pardo, MD
Associate Professor of Neurology and Pathology, The Johns Hopkins Hospital Department of Neurology

Mary Elizabeth Parker, PT, MSPT, PCS, NCS
Department of Physical Therapy, Texas State University, San Marcos

Stephen Shore, PhD
Assistant Professor of Education, Adelphi University; ASA Board of Directors; Author

Timothy Yu, MD
Department of Neurology, LFAC/LADDERS/MGH

Sheldon Wagner, PhD
Director, Behavioral Development and Educational Services, Inc.

Michael Weiss, PhD
Director of Applied Developmental Analysis (ADA) Therapy, LLC; Adjunct Faculty, Psychology, Fairfield University

Rosemary White, OTR/L
Director, Pediatric Physical & Occupational Therapy Services and Pacific Northwest Pediatric

Andy Zimmerman, MD
Pediatric Neurologist, LFAC/LADDERS/MGH

Additional speakers to be announced!

So far, one autistic adult is on the program, Jerry Newport. More autistic adults will be included as well.